دورية أكاديمية
Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma
| العنوان: | Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma |
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| المؤلفون: | Tien-Li Lan, Chun-Fu Lin, Yi-Yen Lee, Ko-Han Lin, Feng-Chi Chang, Shih-Chieh Lin, Jia-Cheng Lee, Fong-In Chou, Jinn-Jer Peir, Hong-Ming Liu, Pei-Fan Mu, Yi-Wei Chen |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 5, p 4978 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | Boron Neutron Capture Therapy (BNCT), targeted radiotherapy, atypical meningioma, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/5/4978; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms24054978 |
| URL الوصول: | https://doaj.org/article/3947b921442248f98594e5877fa793d4 |
| رقم الأكسشن: | edsdoj.3947b921442248f98594e5877fa793d4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms24054978 |