دورية أكاديمية
Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma
| العنوان: | Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma |
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| المؤلفون: | H. Auge, C. Yguel, E. Schmitt, B. Frotscher, H. Busby-Venner, R. Morizot, C. Moulin, P. Feugier, A. Perrot, L. Filliatre-Clement |
| المصدر: | Case Reports in Hematology, Vol 2019 (2019) |
| بيانات النشر: | Hindawi Limited, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | Here, we describe a rare case of acquired von Willebrand syndrome (VWS) associated with intracranial plasmacytoma. The literature includes reports of a few cases of plasmacytoma with central nervous involvement, but none of them with acquired VWS. Diagnosis was made based on a stereotaxic intracerebral biopsy. During this biopsy, a ventriculoperitoneal shunt was established, which was complicated with abnormal bleeding. Subsequent hemostasis assessment related to hemopathy revealed acquired von Willebrand disease. The patient received induction therapy with bortezomib, thalidomide, and dexamethasone (VTD), followed by high-dose melphalan chemotherapy and autologous stem cell transplantation, and then VTD consolidation, and finally maintenance with lenalidomide. Our patient currently remains in very good partial response without neurological symptoms after 4 months of maintenance. The patient is free of progression 14 months after their original presentation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-6560 2090-6579 |
| Relation: | https://doaj.org/toc/2090-6560; https://doaj.org/toc/2090-6579 |
| DOI: | 10.1155/2019/7609308 |
| URL الوصول: | https://doaj.org/article/39793381a795495e953642bc5aa5a2b0 |
| رقم الأكسشن: | edsdoj.39793381a795495e953642bc5aa5a2b0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20906560 20906579 |
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| DOI: | 10.1155/2019/7609308 |