Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

التفاصيل البيبلوغرافية
العنوان:	Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
المؤلفون:	Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
المصدر:	Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
بيانات النشر:	Nature Portfolio, 2018.
سنة النشر:	2018
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to confer potent anti-tumor effects in TNBC.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-018-05763-8
URL الوصول:	https://doaj.org/article/397f4e630bac42c587fdf199a5689e3f
رقم الأكسشن:	edsdoj.397f4e630bac42c587fdf199a5689e3f
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-018-05763-8