Gastroesophageal reflux disease （GERD） is a common recurrent disease and the treatment of GERD is challenging. Chronic heartburn and/or reflux symptoms seriously affect the quality of daily life of patients. Studies have shown that GERD is closely associated with the impairment of anti-reflux barrier of the esophagus，of which mucin （MUC） is the main component. The role of MUC in the pathogenesis of GERD and influencing factors were reviewed in this article.
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