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Trimebutine prevents corneal inflammation in a rat alkali burn model

التفاصيل البيبلوغرافية
العنوان: Trimebutine prevents corneal inflammation in a rat alkali burn model
المؤلفون: Hitoshi Goto, Takeshi Arima, Akira Takahashi, Yutaro Tobita, Yuji Nakano, Etsuko Toda, Akira Shimizu, Fumiki Okamoto
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: HMGB1, RAGE, Trimebutine, Cornea, Alkali burn injury, Inflammation, Medicine, Science
الوصف: Abstract Alkaline burns to the cornea lead to loss of corneal transparency, which is essential for normal vision. We used a rat corneal alkaline burn model to investigate the effect of ophthalmic trimebutine solution on healing wounds caused by alkaline burns. Trimebutine, an inhibitor of the high-mobility group box 1-receptor for advanced glycation end products, when topically applied to the burned cornea, suppressed macrophage infiltration in the early phase and neutrophil infiltration in the late phase at the wound site. It also inhibited neovascularization and myofibroblast development in the late phase. Furthermore, trimebutine effectively inhibited interleukin-1β expression in the injured cornea. It reduced scar formation by decreasing the expression of type III collagen. These findings suggest that trimebutine may represent a novel therapeutic strategy for corneal wounds, not only through its anti-inflammatory effects but also by preventing neovascularization.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-61112-4
URL الوصول: https://doaj.org/article/39ac1a18cf6648be8780d85c30e3435b
رقم الأكسشن: edsdoj.39ac1a18cf6648be8780d85c30e3435b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-61112-4