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Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain.

التفاصيل البيبلوغرافية
العنوان: Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain.
المؤلفون: Diego Lopes Mendes Barretti, Flávio de Castro Magalhães, Tiago Fernandes, Everton Crivoi do Carmo, Kaleizu Teodoro Rosa, Maria Claudia Irigoyen, Carlos Eduardo Negrão, Edilamar Menezes Oliveira
المصدر: PLoS ONE, Vol 7, Iss 10, p e46114 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: OBJECTIVE: Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity and cardiac RAS activation. The study hypothesis was to investigate whether obesity and its association with EXT alter the systemic and cardiac RAS components in an obese Zucker rat strain. METHODS: THE RATS WERE DIVIDED INTO THE FOLLOWING GROUPS: Lean Zucker rats (LZR); lean Zucker rats plus EXT (LZR+EXT); obese Zucker rats (OZR) and obese Zucker rats plus EXT (OZR+EXT). EXT consisted of 10 weeks of 60-min swimming sessions, 5 days/week. At the end of the training protocol heart rate (HR), systolic blood pressure (SBP), cardiac hypertrophy (CH) and function, local and systemic components of RAS were evaluated. Also, systemic glucose, triglycerides, total cholesterol and its LDL and HDL fractions were measured. RESULTS: The resting HR decreased (∼12%) for both LZR+EXT and OZR+EXT. However, only the LZR+EXT reached significance (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3470582?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0046114
URL الوصول: https://doaj.org/article/39b3463aef4c4117b797560f0a0e32cf
رقم الأكسشن: edsdoj.39b3463aef4c4117b797560f0a0e32cf
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0046114