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Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy.

التفاصيل البيبلوغرافية
العنوان: Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy.
المؤلفون: Wino J Wijnen, Ingeborg van der Made, Stephanie van den Oever, Monika Hiller, Bouke A de Boer, Daisy I Picavet, Iliana A Chatzispyrou, Riekelt H Houtkooper, Anke J Tijsen, Jaco Hagoort, Henk van Veen, Vincent Everts, Jan M Ruijter, Yigal M Pinto, Esther E Creemers
المصدر: PLoS ONE, Vol 9, Iss 5, p e96290 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: MicroRNAs (miRNAs) regulate many aspects of cellular function and their deregulation has been implicated in heart disease. MiRNA-30c is differentially expressed in the heart during the progression towards heart failure and in vitro studies hint to its importance in cellular physiology. As little is known about the in vivo function of miRNA-30c in the heart, we generated transgenic mice that specifically overexpress miRNA-30c in cardiomyocytes. We show that these mice display no abnormalities until about 6 weeks of age, but subsequently develop a severely dilated cardiomyopathy. Gene expression analysis of the miRNA-30c transgenic hearts before onset of the phenotype indicated disturbed mitochondrial function. This was further evident by the downregulation of mitochondrial oxidative phosphorylation (OXPHOS) complexes III and IV at the protein level. Taken together these data indicate impaired mitochondrial function due to OXPHOS protein depletion as a potential cause for the observed dilated cardiomyopathic phenotype in miRNA-30c transgenic mice. We thus establish an in vivo role for miRNA-30c in cardiac physiology, particularly in mitochondrial function.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4008570?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0096290
URL الوصول: https://doaj.org/article/39d74b6e26954e6f905a52655dac842b
رقم الأكسشن: edsdoj.39d74b6e26954e6f905a52655dac842b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0096290