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The inflammation paradox: Why are Tsimane protected against Western diseases while Westerners are not? [version 2; peer review: 2 approved, 1 approved with reservations]

التفاصيل البيبلوغرافية
العنوان: The inflammation paradox: Why are Tsimane protected against Western diseases while Westerners are not? [version 2; peer review: 2 approved, 1 approved with reservations]
المؤلفون: Jens Freese, Rainer Johannes Klement, Helmut Lötzerich
المصدر: F1000Research, Vol 7 (2018)
بيانات النشر: F1000 Research Ltd, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: We here describe two apparent paradoxes concerning high CRP levels and NCD risk. One has emerged from observational studies in the Amazon region showing that the indigenous Tsimane in Bolivia appear protected against non-communicable diseases (NCDs) such as obesity, type 2 diabetes, and cardiovascular diseases despite increased inflammatory markers. These findings stand in contrast to Western societies, where an increasing body of evidence demonstrates that low-grade-inflammation is the driver of NCDs. The second paradox has emerged from two field studies (Eifel studies) conducted in 2013 and 2014 with Westerners who returned to a simulated Palaeolithic lifestyle in a National park for 4 days. We had detected elevated inflammation markers, despite otherwise anti-inflammatory effects of these interventions as indicated by metabolic blood parameters. We here propose three hypotheses for this second inflammatory paradox.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2046-1402
Relation: https://f1000research.com/articles/7-252/v2; https://doaj.org/toc/2046-1402
DOI: 10.12688/f1000research.14052.2
URL الوصول: https://doaj.org/article/39f12b836893448eaf8efdbcad6662a7
رقم الأكسشن: edsdoj.39f12b836893448eaf8efdbcad6662a7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20461402
DOI:10.12688/f1000research.14052.2