دورية أكاديمية
Ascorbate protects liver from metabolic disorder through inhibition of lipogenesis and suppressor of cytokine signaling 3 (SOCS3)
| العنوان: | Ascorbate protects liver from metabolic disorder through inhibition of lipogenesis and suppressor of cytokine signaling 3 (SOCS3) |
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| المؤلفون: | Yingying Xu, Yuhang Wu, Yue Xiong, Jiawang Tao, Tingcai Pan, Shenglin Tan, Ge Gao, Yan Chen, Nasir Abbas, Anteneh Getachew, Yuanqi Zhuang, Kai You, Fan Yang, Yin-xiong Li |
| المصدر: | Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-10 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | Guinea pig, Lipidomics, Lipogenesis, Insulin signaling, STAT3, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Abstract Background Fatty liver is a reversible status, but also an origin stage to develop to other metabolic syndromes, such as diabetes and heart disease that threatens public health worldwide. Ascorbate deficiency is reported to be correlated with increasing risks for metabolic syndromes, but whether ascorbate has a therapeutic effect is unknown. Here, we investigated if ascorbate treatment alone could work on protecting from the development of steatosis and mechanisms beyond. Methods Guinea pigs were fed with a chow diet or a high palm oil diet (HPD) respectively. HPD induced animals were administered different concentrations of ascorbate in different time intervals through water. Besides, hepatocyte-like cells derived from human embryonic stem cells and HepG2 cells were treated with palmitic acid (PA) to induce lipid accumulation for molecular mechanism study. Results We find that ascorbate rescues HPD and PA induced steatosis and insulin tolerance in vivo and in vitro. We demonstrate that ascorbate changes cellular lipid profiles via inhibits lipogenesis, and inhibits the expression of SOCS3 via STAT3, thus enhances insulin signal transduction. Overexpression of SOCS3 abolishes the ascorbate rescue effects on insulin signal and lipid accumulation in hepatic cells. Conclusions Ascorbate ameliorates hepatic steatosis and improves insulin sensitivity through inhibiting lipogenesis and SOCS3. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1743-7075 |
| Relation: | http://link.springer.com/article/10.1186/s12986-020-0431-y; https://doaj.org/toc/1743-7075 |
| DOI: | 10.1186/s12986-020-0431-y |
| URL الوصول: | https://doaj.org/article/39ff0ca184be48269aa2af9a8aad36dd |
| رقم الأكسشن: | edsdoj.39ff0ca184be48269aa2af9a8aad36dd |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17437075 |
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| DOI: | 10.1186/s12986-020-0431-y |