دورية أكاديمية
The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake
| العنوان: | The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake |
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| المؤلفون: | João Paulo Guilherme, Edit Bosnyák, Ekaterina Semenova, Márta Szmodis, Annamária Griff, Ákos Móra, Gábor Almási, Emese Trájer, Anna Udvardy, Elena Kostryukova, Oleg Borisov, Andrey Larin, Liliya Andryushchenko, Egor Akimov, Edward Generozov, Ildus Ahmetov, Miklós Tóth, Antonio Lancha Junior |
| المصدر: | Biology of Sport, Vol 38, Iss 3, Pp 465-474 (2020) |
| بيانات النشر: | Termedia Publishing House, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Sports medicine LCC:Biology (General) |
| مصطلحات موضوعية: | aerobic performance, aerobic power, athletes, erythrocytes, genetics monocarboxylate transporter, Sports medicine, RC1200-1245, Biology (General), QH301-705.5 |
| الوصف: | The purpose of this study was to explore the association of the MCT1 gene Glu490Asp polymorphism (rs1049434) with athletic status and performance of endurance athletes. A total of 1,208 Brazilians (318 endurance athletes and 890 non-athletes) and 867 Europeans (315 endurance athletes and 552 non-athletes) were evaluated in a case–control approach. Brazilian participants were classified based on self-declared ethnicity to test whether the polymorphism was different between Caucasians and Afro-descendants. Moreover, 66 Hungarian athletes underwent an incremental test until exhaustion to assess blood lactate levels, while 46 Russian athletes had their maximum oxygen uptake (O2max) compared between genotypes. In the Brazilian cohort, the major T-allele was more frequent in Caucasian top-level competitors compared to their counterparts of lower competitive level (P = 0.039), and in Afro-descendant athletes compared to non-athletes (P = 0.015). Similarly, the T-allele was more frequent in European athletes (P = 0.029). Meta-analysis of the Brazilian and European cohorts confirmed that the T-allele is over-represented in endurance athletes (OR: 1.48, P = 0.03), especially when Afro-descendant athletes were included in the meta-analysis (OR: 1.58, P = 0.005). Furthermore, carriers of the T/T genotype accumulated less blood lactate in response to intense effort (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0860-021X 2083-1862 |
| Relation: | https://www.termedia.pl/The-MCT1-gene-Glu490Asp-polymorphism-rs1049434-r-nis-associated-with-endurance-athlete-status-lower-blood-lactate-r-naccumulation-and-higher-maximum-oxygen-uptake,78,42652,1,1.html; https://doaj.org/toc/0860-021X; https://doaj.org/toc/2083-1862 |
| DOI: | 10.5114/biolsport.2021.101638 |
| URL الوصول: | https://doaj.org/article/3a09959dbfc44d1da1ce99dba902580c |
| رقم الأكسشن: | edsdoj.3a09959dbfc44d1da1ce99dba902580c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 0860021X 20831862 |
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| DOI: | 10.5114/biolsport.2021.101638 |