دورية أكاديمية
Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-Deficient Mice in a Diet-Dependent Manner, Irrespective of Sex
| العنوان: | Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-Deficient Mice in a Diet-Dependent Manner, Irrespective of Sex |
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| المؤلفون: | Jules Mérian, Lamia Ghezali, Charlotte Trenteseaux, Thibaut Duparc, Diane Beuzelin, Vanessa Bouguetoch, Guillaume Combes, Nabil Sioufi, Laurent O. Martinez, Souad Najib |
| المصدر: | Cells, Vol 12, Iss 4, p 533 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | intermittent fasting, glucose tolerance, hepatic steatosis, adipose tissue, reverse cholesterol transport, atherosclerosis, Cytology, QH573-671 |
| الوصف: | In humans and animal models, intermittent fasting (IF) interventions promote body weight loss, improve metabolic health, and are thought to lower cardiovascular disease risk. However, there is a paucity of reports on the relevance of such nutritional interventions in the context of dyslipidemia and atherosclerotic cardiovascular diseases. The present study assessed the metabolic and atheroprotective effects of intermittent fasting intervention (IF) in atherosclerosis-prone apolipoprotein E-deficient (Apoe-/-) mice. Groups of male and female Apoe-/- mice were fed a regular (chow) or atherogenic (high-fat, high-cholesterol, HFCD) diet for 4 months, either ad libitum or in an alternate-day fasting manner. The results show that IF intervention improved glucose and lipid metabolism independently of sex. However, IF only decreased body weight gain in males fed chow diet and differentially modulated adipose tissue parameters and liver steatosis in a diet composition-dependent manner. Finally, IF prevented spontaneous aortic atherosclerotic lesion formation in mice fed chow diet, irrespective of sex, but failed to reduce HFCD-diet-induced atherosclerosis. Overall, the current work indicates that IF interventions can efficiently improve glucose homeostasis and treat atherogenic dyslipidemia, but a degree of caution is warranted with regard to the individual sex and the composition of the dietary regimen. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12040533 2073-4409 |
| Relation: | https://www.mdpi.com/2073-4409/12/4/533; https://doaj.org/toc/2073-4409 |
| DOI: | 10.3390/cells12040533 |
| URL الوصول: | https://doaj.org/article/3a0bf10cf1d54cbf8fc08c0ff8d74421 |
| رقم الأكسشن: | edsdoj.3a0bf10cf1d54cbf8fc08c0ff8d74421 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12040533 20734409 |
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| DOI: | 10.3390/cells12040533 |