دورية أكاديمية
Are there differences in oxidative stress and inflammatory processes between the autogenous and reactive subtypes of obsessive-compulsive disorder? A controlled cross-sectional study
| العنوان: | Are there differences in oxidative stress and inflammatory processes between the autogenous and reactive subtypes of obsessive-compulsive disorder? A controlled cross-sectional study |
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| المؤلفون: | Melis Danışman Sonkurt, Ali E. Altınöz, Ferdi Köşger, Semra Yiğitaslan, Gülcan Güleç, Altan Eşsizoğlu |
| المصدر: | Brazilian Journal of Psychiatry (2021) |
| بيانات النشر: | Associação Brasileira de Psiquiatria (ABP), 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Psychiatry |
| مصطلحات موضوعية: | Obsessive-compulsive disorder, oxidative stress, inflammatory process, autogenous, reactive, Psychiatry, RC435-571 |
| الوصف: | Objective: To date, no study has investigated whether autogenous and reactive obsessive-compulsive disorder (OCD) types are different entities in terms of oxidative stress and inflammatory processes. The aim of this study is to compare them in terms of these features. Methods: The study was conducted in subjects with reactive OCD (n=19), autogenous OCD (n=14), and a control group (n=17). All participants were non-smokers. Sociodemographic data were collected and the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Obsessive Beliefs Questionnaire (OBQ), and Overvalued Ideas Scale (OVIS) were administered. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-10 (IL-10), paraoxonase (PON1), total oxidant status (TOS), and total antioxidant status (TAS) were measured. Results: There were no significant differences in TAS, TOS, or oxidative stress index (OSI) between the OCD and control groups. PON1 and hs-CRP levels were higher in the OCD group, whereas IL-6 and IL-10 levels were lower. Comparison across the three groups revealed no differences in TAS, TOS, OSI, or PON1 levels; however, hs-CRP was significantly higher while IL-6 and IL-10 were significantly lower in the reactive group compared to controls. Conclusion: Our results show that, although inflammatory processes may play a role in OCD, the autogenous and reactive subtypes do not differ from each other in these respects. The classification of OCD into autogenous and reactive subtypes should be reevaluated. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 1809-452X 1516-4446 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462021005020203&tlng=en; https://doaj.org/toc/1809-452X |
| DOI: | 10.1590/1516-4446-2021-1740 |
| URL الوصول: | https://doaj.org/article/3a227b553cf54a01a70b2c2150405c72 |
| رقم الأكسشن: | edsdoj.3a227b553cf54a01a70b2c2150405c72 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1809452X 15164446 |
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| DOI: | 10.1590/1516-4446-2021-1740 |