دورية أكاديمية
A Novel Urine Test Biosensor Platform for Early Lung Cancer Detection
| العنوان: | A Novel Urine Test Biosensor Platform for Early Lung Cancer Detection |
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| المؤلفون: | Ory Wiesel, Sook-Whan Sung, Amit Katz, Raya Leibowitz, Jair Bar, Iris Kamer, Itay Berger, Inbal Nir-Ziv, Michal Mark Danieli |
| المصدر: | Biosensors, Vol 13, Iss 6, p 627 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology |
| مصطلحات موضوعية: | lung cancer, early diagnosis, screening, early detection, volatile organic compound, biosensors, Biotechnology, TP248.13-248.65 |
| الوصف: | Lung cancer is the leading cause of cancer-related mortality worldwide. Early detection is essential to achieving a better outcome and prognosis. Volatile organic compounds (VOCs) reflect alterations in the pathophysiology and body metabolism processes, as shown in various types of cancers. The biosensor platform (BSP) urine test uses animals’ unique, proficient, and accurate ability to scent lung cancer VOCs. The BSP is a testing platform for the binary (negative/positive) recognition of the signature VOCs of lung cancer by trained and qualified Long–Evans rats as biosensors (BSs). The results of the current double-blind study show high accuracy in lung cancer VOC recognition, with 93% sensitivity and 91% specificity. The BSP test is safe, rapid, objective and can be performed repetitively, enabling periodic cancer monitoring as well as an aid to existing diagnostic methods. The future implementation of such urine tests as routine screening and monitoring tools has the potential to significantly increase detection rate as well as curability rates with lower healthcare expenditure. This paper offers a first instructive clinical platform utilizing VOC’s in urine for detection of lung cancer using the innovative BSP to deal with the pressing need for an early lung cancer detection test tool. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13060627 2079-6374 |
| Relation: | https://www.mdpi.com/2079-6374/13/6/627; https://doaj.org/toc/2079-6374 |
| DOI: | 10.3390/bios13060627 |
| URL الوصول: | https://doaj.org/article/eccccaa3a52f43a392b83da4c5ac8835 |
| رقم الأكسشن: | edsdoj.3a52f43a392b83da4c5ac8835 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13060627 20796374 |
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| DOI: | 10.3390/bios13060627 |