دورية أكاديمية
Non-ionotropic voltage-gated calcium channel signaling
| العنوان: | Non-ionotropic voltage-gated calcium channel signaling |
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| المؤلفون: | Michael Trus, Daphne Atlas |
| المصدر: | Channels, Vol 18, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Physiology |
| مصطلحات موضوعية: | Excitation transcription (ET) coupling, CICR, cardiac excitation contraction (EC) coupling, synaptic transmission, L-type Ca2+ channel, conformational coupling, Therapeutics. Pharmacology, RM1-950, Physiology, QP1-981 |
| الوصف: | ABSTRACTVoltage-gated calcium channels (VGCCs) are the major conduits for calcium ions (Ca2+) within excitable cells. Recent studies have highlighted the non-ionotropic functionality of VGCCs, revealing their capacity to activate intracellular pathways independently of ion flow. This non-ionotropic signaling mode plays a pivotal role in excitation-coupling processes, including gene transcription through excitation-transcription (ET), synaptic transmission via excitation-secretion (ES), and cardiac contraction through excitation-contraction (EC). However, it is noteworthy that these excitation-coupling processes require extracellular calcium (Ca2+) and Ca2+ occupancy of the channel ion pore. Analogous to the “non-canonical” characterization of the non-ionotropic signaling exhibited by the N-methyl-D-aspartate receptor (NMDA), which requires extracellular Ca2+ without the influx of ions, VGCC activation requires depolarization-triggered conformational change(s) concomitant with Ca2+ binding to the open channel. Here, we discuss the contributions of VGCCs to ES, ET, and EC coupling as Ca2+ binding macromolecules that transduces external stimuli to intracellular input prior to elevating intracellular Ca2+. We emphasize the recognition of calcium ion occupancy within the open ion-pore and its contribution to the excitation coupling processes that precede the influx of calcium. The non-ionotropic activation of VGCCs, triggered by the upstroke of an action potential, provides a conceptual framework to elucidate the mechanistic aspects underlying the microseconds nature of synaptic transmission, cardiac contractility, and the rapid induction of first-wave genes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 19336950 1933-6969 1933-6950 |
| Relation: | https://doaj.org/toc/1933-6950; https://doaj.org/toc/1933-6969 |
| DOI: | 10.1080/19336950.2024.2341077 |
| URL الوصول: | https://doaj.org/article/3a62bedef9c64c1b918acd8e031fe477 |
| رقم الأكسشن: | edsdoj.3a62bedef9c64c1b918acd8e031fe477 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 19336950 19336969 |
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| DOI: | 10.1080/19336950.2024.2341077 |