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Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope

التفاصيل البيبلوغرافية
العنوان: Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope
المؤلفون: Xiaoxuan Zhong, Yizhi Liang, Xiaoyu Wang, Haoying Lan, Xue Bai, Long Jin, Bai-Ou Guan
المصدر: Light: Science & Applications, Vol 13, Iss 1, Pp 1-14 (2024)
بيانات النشر: Nature Publishing Group, 2024.
سنة النشر: 2024
المجموعة: LCC:Applied optics. Photonics
LCC:Optics. Light
مصطلحات موضوعية: Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
الوصف: Abstract We report the development of a head-mounted photoacoustic fiberscope for cerebral imaging in a freely behaving mouse. The 4.5-gram imaging probe has a 9-µm lateral resolution and 0.2-Hz frame rate over a 1.2-mm wide area. The probe can continuously monitor cerebral oxygenation and hemodynamic responses at single-vessel resolution, showing significantly different cerebrovascular responses to external stimuli under anesthesia and in the freely moving state. For example, when subjected to high-concentration CO2 respiration, enhanced oxygenation to compensate for hypercapnia can be visualized due to cerebral regulation in the freely moving state. Comparative studies exhibit significantly weakened compensation capabilities in obese rodents. This new imaging modality can be used for investigating both normal and pathological cerebrovascular functions and shows great promise for studying cerebral activity, disorders and their treatments.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2047-7538
Relation: https://doaj.org/toc/2047-7538
DOI: 10.1038/s41377-023-01348-3
URL الوصول: https://doaj.org/article/3a7ea0e20e944aab8ac20cfc7266ec2f
رقم الأكسشن: edsdoj.3a7ea0e20e944aab8ac20cfc7266ec2f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20477538
DOI:10.1038/s41377-023-01348-3