دورية أكاديمية
Catecholamine Derivatives as Novel Crosslinkers for the Synthesis of Versatile Biopolymers
| العنوان: | Catecholamine Derivatives as Novel Crosslinkers for the Synthesis of Versatile Biopolymers |
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| المؤلفون: | Manickam Sugumaran, Jason J. Evans |
| المصدر: | Journal of Functional Biomaterials, Vol 14, Iss 9, p 449 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Medicine (General) |
| مصطلحات موضوعية: | dopa, dopamine, N-acyldopamines, tunichromes, dopyl proteins, sclerotization, Biotechnology, TP248.13-248.65, Medicine (General), R5-920 |
| الوصف: | Catecholamine metabolites are not only involved in primary metabolism, but also in secondary metabolism, serving a diverse array of physiologically and biochemically important functions. Melanin, which originates from dopa and dopamine, found in the hair, eye, and skin of all animals, is an important biopolymeric pigment. It provides protection against damaging solar radiation to animals. N-Acetyldopamine and N-β-alanyldopamine play a crucial role in the hardening of the exoskeletons of all insects. In addition, insects and other arthropods utilize the melanogenic process as a key component of their defense systems. Many marine organisms utilize dopyl peptides and proteins as bonding materials to adhere to various substrata. Moreover, the complex dopa derivatives that are precursors to the formation of the exoskeletons of numerous marine organisms also exhibit antibiotic properties. The biochemistry and mechanistic transformations of different catecholamine derivatives to produce various biomaterials with antioxidant, antibiotic, crosslinking, and gluing capabilities are highlighted. These reactivities are exhibited through the transient and highly reactive quinones, quinone methides, and quinone methide imine amide intermediates, as well as chelation to metal ions. A careful consideration of the reactivities summarized in this review will inspire numerous strategies for synthesizing novel biomaterials for future medical and industrial use. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14090449 2079-4983 |
| Relation: | https://www.mdpi.com/2079-4983/14/9/449; https://doaj.org/toc/2079-4983 |
| DOI: | 10.3390/jfb14090449 |
| URL الوصول: | https://doaj.org/article/3aadd2a8ec63466baf350f68a86d6b00 |
| رقم الأكسشن: | edsdoj.3aadd2a8ec63466baf350f68a86d6b00 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14090449 20794983 |
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| DOI: | 10.3390/jfb14090449 |