دورية أكاديمية
Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center
| العنوان: | Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center |
|---|---|
| المؤلفون: | Danish Abdul Aziz, Syeda Khadija Fatima, Haissan Iftikhar, Fatima Mir |
| المصدر: | Lung India, Vol 38, Iss 4, Pp 326-329 (2021) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | 25-hydroxyvitamin d (25-ohd), cystic fibrosis, pseudomonas colonization, pulmonary exacerbations, vitamin d deficiency, Diseases of the respiratory system, RC705-779 |
| الوصف: | Background: The function of Vitamin D in preventing inflammation and infection has been studied previously for different pathologies in different populations globally. Relationships between serum Vitamin D levels and its effect on pulmonary exacerbations in the cystic fibrosis (CF) population are not well studied in our part of the world. Therefore, we aimed to ascertain the Vitamin D status in pediatric and adolescent CF patients and its association with pulmonary exacerbations. Materials and Methods: A retrospective study was conducted at The Aga Khan University Hospital from 2015 to 2018. Patients of CF with sweat chloride value >60 mmol/l and who had at least one measurement of 25 hydroxy Vitamin D (25 OHD) were included in the study. Annual serum Vitamin D levels were documented for enrolled patients and their past 1-year data were analyzed for pulmonary exacerbations, average length of stay, and tracheal/airway colonization with organisms. Results: 69 patients were included in the study. 28 patients (40.57%) were found to be Vitamin D deficient, 22 patients (31.88%) were Vitamin D insufficient and 19 patients (27.53%) were labeled as Vitamin D insufficient. The average number of exacerbations per year was significantly high in Vitamin D deficient group (3.71 ± 0.96) in comparison with insufficient (3.18 ± 1.09) and sufficient groups (2.26 ± 0.93) (P < 0.001). Conclusion: Vitamin D deficiency is related to an increased number of annual pulmonary exacerbations and pseudomonas infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0970-2113 0974-598X |
| Relation: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=4;spage=326;epage=329;aulast=Aziz; https://doaj.org/toc/0970-2113; https://doaj.org/toc/0974-598X |
| DOI: | 10.4103/lungindia.lungindia_589_20 |
| URL الوصول: | https://doaj.org/article/3adaf310bc474b45a07b26ff553b7581 |
| رقم الأكسشن: | edsdoj.3adaf310bc474b45a07b26ff553b7581 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09702113 0974598X |
|---|---|
| DOI: | 10.4103/lungindia.lungindia_589_20 |