دورية أكاديمية
Synthesis, Photochemistry, Computational Study and Potential Application of New Styryl-Thiophene and Naphtho-Thiophene Benzylamines
| العنوان: | Synthesis, Photochemistry, Computational Study and Potential Application of New Styryl-Thiophene and Naphtho-Thiophene Benzylamines |
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| المؤلفون: | Milena Mlakić, Ilijana Odak, Ivan Faraho, Martina Bosnar, Mihailo Banjanac, Zlata Lasić, Željko Marinić, Danijela Barić, Irena Škorić |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 1, p 610 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | acid resistance, benzylamines, DFT, heterostilbenes, molecular docking, photocyclization, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | In this research, the synthesis, photochemistry, and computational study of new cis- and trans-isomers of amino-thienostilbenes is performed to test the efficiency of their production and acid resistance, and to investigate their electronic structure, photoreactivity, photophysical characteristics, and potential biological activity. The electronic structure and conformations of synthesized thienostilbene amines and their photocyclization products are examined computationally, along with molecular modeling of amines possessing two thiophene rings that showed inhibitory potential toward cholinesterases. New amino-styryl thiophenes, with favorable photophysical properties and proven acid resistance, represent model compounds for their water-soluble ammonium salts as potential styryl optical dyes. The comparison with organic dyes possessing a trans-aminostilbene subunit as the scaffold shows that the newly synthesized trans-aminostilbenes have very similar absorbance wavelengths. Furthermore, their functionalized cis-isomers and photocyclization products are good candidates for cholinesterase inhibitors because of the structural similarity of the molecular skeleton to some already proven bioactive derivatives. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 30443296 |
| Relation: | https://www.mdpi.com/1422-0067/24/1/610; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms24010610 |
| URL الوصول: | https://doaj.org/article/ed3addafde30443296e872e45b97d86f |
| رقم الأكسشن: | edsdoj.3addafde30443296e872e45b97d86f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 30443296 |
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| DOI: | 10.3390/ijms24010610 |