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ABHD5—A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions

التفاصيل البيبلوغرافية
العنوان: ABHD5—A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions
المؤلفون: Margarita Schratter, Achim Lass, Franz P. W. Radner
المصدر: Metabolites, Vol 12, Iss 11, p 1015 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Microbiology
مصطلحات موضوعية: ABHD5, CGI-58, ATGL, PNPLA3, triglyceride, lipid metabolism, Microbiology, QR1-502
الوصف: The α/β-Hydrolase domain-containing protein 5 (ABHD5; also known as comparative gene identification-58, or CGI-58) is the causative gene of the Chanarin-Dorfman syndrome (CDS), a disorder mainly characterized by systemic triacylglycerol accumulation and a severe defect in skin barrier function. The clinical phenotype of CDS patients and the characterization of global and tissue-specific ABHD5-deficient mouse strains have demonstrated that ABHD5 is a crucial regulator of lipid and energy homeostasis in various tissues. Although ABHD5 lacks intrinsic hydrolase activity, it functions as a co-activating enzyme of the patatin-like phospholipase domain-containing (PNPLA) protein family that is involved in triacylglycerol and glycerophospholipid, as well as sphingolipid and retinyl ester metabolism. Moreover, ABHD5 interacts with perilipins (PLINs) and fatty acid-binding proteins (FABPs), which are important regulators of lipid homeostasis in adipose and non-adipose tissues. This review focuses on the multifaceted role of ABHD5 in modulating the function of key enzymes in lipid metabolism.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 12111015
2218-1989
Relation: https://www.mdpi.com/2218-1989/12/11/1015; https://doaj.org/toc/2218-1989
DOI: 10.3390/metabo12111015
URL الوصول: https://doaj.org/article/3b11d410a9e9417f913aadc44683e55c
رقم الأكسشن: edsdoj.3b11d410a9e9417f913aadc44683e55c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:12111015
22181989
DOI:10.3390/metabo12111015