دورية أكاديمية
The pattern of X-inactivation in Human X-linked Disorders and their Model Organisms: A literature review
| العنوان: | The pattern of X-inactivation in Human X-linked Disorders and their Model Organisms: A literature review |
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| المؤلفون: | Zhou Yixin |
| المصدر: | E3S Web of Conferences, Vol 145, p 01008 (2020) |
| بيانات النشر: | EDP Sciences, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Environmental sciences |
| مصطلحات موضوعية: | Environmental sciences, GE1-350 |
| الوصف: | X-inactivation is a strategy in female mammals aiming at maximizing gene inactivation of one single X chromosome in order to balance X dosage between males and females. Various human X-linked disorders have been reported related to one or more X-inactivation patterns. It is necessary to understand their relationship to study X-linked disorders. Current researches largely rely on clinical phenotype research and model organism. Considering the differences between human and model organisms, it is vital to find a suitable model of a specific disorder. The paper reviews different patterns and specific disorders linked with X-inac tivation. Also, the advantages and disadvantages of applying specific model organisms in different disorders will be discussed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English French |
| تدمد: | 2267-1242 |
| Relation: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/05/e3sconf_iaecst2020_01008.pdf; https://doaj.org/toc/2267-1242 |
| DOI: | 10.1051/e3sconf/202014501008 |
| URL الوصول: | https://doaj.org/article/e3b264fee12c46c69ba92c8d66fe6a32 |
| رقم الأكسشن: | edsdoj.3b264fee12c46c69ba92c8d66fe6a32 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22671242 |
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| DOI: | 10.1051/e3sconf/202014501008 |