Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression

التفاصيل البيبلوغرافية
العنوان:	Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
المؤلفون:	Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu, Qing-Bai She
المصدر:	Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
بيانات النشر:	Nature Portfolio, 2020.
سنة النشر:	2020
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Polyamine metabolism is frequently dysregulated in cancers. Here, the authors show that a polyamine biosynthetic enzyme, spermine synthase, is overexpressed in colorectal cancers and cooperates with MYC to prevent cancer cell apoptosis by repression of proapoptotic protein, Bim.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-020-17067-x
URL الوصول:	https://doaj.org/article/3b2da2db381e4fd0ae6f0d0669ca275b
رقم الأكسشن:	edsdoj.3b2da2db381e4fd0ae6f0d0669ca275b
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-020-17067-x