دورية أكاديمية
أعرض في EDS

Novel Resin-Based Antibacterial Root Surface Coating Material to Combat Dental Caries

التفاصيل البيبلوغرافية
العنوان: Novel Resin-Based Antibacterial Root Surface Coating Material to Combat Dental Caries
المؤلفون: Nader Almutairi, Abdullah Alhussein, Mohammad Alenizy, Ibrahim Ba-Armah, Jirun Sun, Michael D. Weir, Hockin H. K. Xu
المصدر: Journal of Functional Biomaterials, Vol 15, Iss 6, p 168 (2024)
بيانات النشر: MDPI AG, 2024.
سنة النشر: 2024
المجموعة: LCC:Biotechnology
LCC:Medicine (General)
مصطلحات موضوعية: coating, resin, antibacterial, oral biofilm, root caries, Biotechnology, TP248.13-248.65, Medicine (General), R5-920
الوصف: Root caries caused by cariogenic bacteria are a burden on a large number of individuals worldwide, especially the elderly. Applying a protective coating to exposed root surfaces has the potential to inhibit the development of caries, thus preserving natural teeth. This study aimed to develop a novel antibacterial coating to combat root caries and evaluate its effectiveness using the antibacterial monomer dimethylaminohexadecyl methacrylate (DMAHDM). DMAHDM was synthesized and incorporated into a resin consisting of 55.8% urethane dimethacrylate (UDMA) and 44.2% TEG-DVBE (UV) at a 10% mass fraction of glass filler. Multiple concentrations of DMAHDM were tested for their impact on the resin’s mechanical and physical properties. S. mutans biofilms grown on resin disks were analyzed for antibacterial efficacy. Cytotoxicity was assessed against human gingival fibroblasts (HGFs). The results showed an 8-log reduction in colony-forming units (CFUs) against S. mutans biofilm (mean ± sd; n = 6) (p < 0.05) when 5% DMAHDM was incorporated into the UV resin. There was a 90% reduction in metabolic activity and lactic acid production. A low level of cytotoxicity against HGF was observed without compromising the physical and mechanical properties of the resin. This coating material demonstrated promising physical properties, potent antibacterial effects, and low toxicity, suggesting its potential to protect exposed roots from caries in various dental procedures and among elderly individuals with gingival recession.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2079-4983
Relation: https://www.mdpi.com/2079-4983/15/6/168; https://doaj.org/toc/2079-4983
DOI: 10.3390/jfb15060168
URL الوصول: https://doaj.org/article/3b68243a8afc4d3fa4230b9131b36c32
رقم الأكسشن: edsdoj.3b68243a8afc4d3fa4230b9131b36c32
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20794983
DOI:10.3390/jfb15060168