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Antiviral treatment associated with reduced risk of clinical Alzheimer's disease—A nested case‐control study

التفاصيل البيبلوغرافية
العنوان: Antiviral treatment associated with reduced risk of clinical Alzheimer's disease—A nested case‐control study
المؤلفون: Eva‐Stina Hemmingsson, Ellen Hjelmare, Bodil Weidung, Jan Olsson, Maria Josefsson, Rolf Adolfsson, Lars Nyberg, Fredrik Elgh, Hugo Lövheim
المصدر: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)
بيانات النشر: Wiley, 2021.
سنة النشر: 2021
المجموعة: LCC:Neurology. Diseases of the nervous system
LCC:Geriatrics
مصطلحات موضوعية: Alzheimer's disease, antiviral treatment, apolipoprotein E gene, dementia, herpes simplex, major neurocognitive disorder, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6
الوصف: Abstract Introduction In this nested case‐control study, we investigated if antiviral treatment given prior to onset of Alzheimer's disease (AD) could influence incident AD. Methods From a large population‐based cohort study in northern Sweden, 262 individuals that later developed AD were compared to a non‐AD matched control group with respect to prescriptions of herpes antiviral treatment. All included subjects were herpes simplex virus 1 (HSV1) carriers and the matching criteria were age, sex, apolipoprotein E genotype (ε4 allele carriership), and study sample start year. Results Among those who developed AD, 6 prescriptions of antivirals were found, compared to 20 among matched controls. Adjusted for length of follow‐up, a conditional logistic regression indicated a difference in the risk for AD development between groups (odds ratio for AD with an antiviral prescription 0.287, P = .018). Discussion Antiviral treatment might possibly reduce the risk for later development of HSV1‐associated AD.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2352-8737
Relation: https://doaj.org/toc/2352-8737
DOI: 10.1002/trc2.12187
URL الوصول: https://doaj.org/article/d3ba3b417cbd436c8b4546d35ba80212
رقم الأكسشن: edsdoj.3ba3b417cbd436c8b4546d35ba80212
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23528737
DOI:10.1002/trc2.12187