دورية أكاديمية
Assessment of iridoid profiles in the growth period of aerial parts of Pseudolysimachion rotundum var. subintegrum and their antioxidant and MUC5AC inhibitory potential
| العنوان: | Assessment of iridoid profiles in the growth period of aerial parts of Pseudolysimachion rotundum var. subintegrum and their antioxidant and MUC5AC inhibitory potential |
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| المؤلفون: | Soobin Song, Doo-Young Kim, Seon Min Oh, So-Yeun Woo, Il-joo Kim, Mun-Ock Kim, Ji-Yoon Park, Namho Kim, Hae-Young Kim, Juhee Lee, Sang Yoon Kim, Bang Yeon Hwang, Hyung Won Ryu, Sei-Ryang Oh |
| المصدر: | Applied Biological Chemistry, Vol 66, Iss 1, Pp 1-14 (2023) |
| بيانات النشر: | SpringerOpen, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Agriculture (General) LCC:Chemistry |
| مصطلحات موضوعية: | Pseudolysimachion rotundum var. Subintegrum, Growth stages, Quality control, Antioxidant, MUC5AC, Agriculture (General), S1-972, Chemistry, QD1-999 |
| الوصف: | Abstract YPL-001 is a drug substance of Pseudolysimachion rotundum var. subintegrum and has been reported to be a potent COPD inhibitor. For the first time, this study demonstrated a correlation among the iridoid constituents, antioxidants, and MUC5AC inhibition activities in P. rotundum during different growth stages (5 to 11 weeks). Single-factor extraction was used to optimize the plant extraction conditions to maximize the major iridoid constituents (70% ethanol, 40 °C, 1 h); isolated metabolites 1–6 were identified using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). The contents of each metabolite and antioxidant/MUC5AC inhibition effects were markedly changed according to the growth stages, especially for catalposide (2, 5.97 → 10.99 mg/g, 1.8-fold) and isovanillyl catapol (5, 4.42 → 20.00 mg/g, 4.5-fold), which were the predominant substances in August. Our results indicated that YPL-001 could potentially contribute to enhancing the P. rotundum value in accumulated iridoids at the growth stage and the biological effect aspects to develop industrial medicinal crops. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2468-0842 |
| Relation: | https://doaj.org/toc/2468-0842 |
| DOI: | 10.1186/s13765-023-00796-0 |
| URL الوصول: | https://doaj.org/article/3ba4370a878542c28f770a0e80c08c6a |
| رقم الأكسشن: | edsdoj.3ba4370a878542c28f770a0e80c08c6a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24680842 |
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| DOI: | 10.1186/s13765-023-00796-0 |