دورية أكاديمية
Vanin 1: Its Physiological Function and Role in Diseases
| العنوان: | Vanin 1: Its Physiological Function and Role in Diseases |
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| المؤلفون: | Roberta Bartucci, Anna Salvati, Peter Olinga, Ykelien L. Boersma |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 16, p 3891 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | vanin 1, oxidative stress, PPAR-alpha, PPAR-gamma, urinary biomarker, pro-inflammatory role, protective role, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The enzyme vascular non-inflammatory molecule-1 (vanin 1) is highly expressed at gene and protein level in many organs, such as the liver, intestine, and kidney. Its major function is related to its pantetheinase activity; vanin 1 breaks down pantetheine in cysteamine and pantothenic acid, a precursor of coenzyme A. Indeed, its physiological role seems strictly related to coenzyme A metabolism, lipid metabolism, and energy production. In recent years, many studies have elucidated the role of vanin 1 under physiological conditions in relation to oxidative stress and inflammation. Vanin’s enzymatic activity was found to be of key importance in certain diseases, either for its protective effect or as a sensitizer, depending on the diseased organ. In this review, we discuss the role of vanin 1 in the liver, kidney, intestine, and lung under physiological as well as pathophysiological conditions. Thus, we provide a more complete understanding and overview of its complex function and contribution to some specific pathologies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | https://www.mdpi.com/1422-0067/20/16/3891; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms20163891 |
| URL الوصول: | https://doaj.org/article/3c177aa08c0b41e4976dae4743db7241 |
| رقم الأكسشن: | edsdoj.3c177aa08c0b41e4976dae4743db7241 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms20163891 |