دورية أكاديمية
أعرض في EDS

EGFR as a biomarker of smoking status and survival in oropharyngeal squamous cell carcinoma

التفاصيل البيبلوغرافية
العنوان: EGFR as a biomarker of smoking status and survival in oropharyngeal squamous cell carcinoma
المؤلفون: Shanmugappiriya Sivarajah, Morris Kostiuk, Cameron Lindsay, Lakshmi Puttagunta, Daniel A. O’Connell, Jeffrey Harris, Hadi Seikaly, Vincent L. Biron
المصدر: Journal of Otolaryngology - Head and Neck Surgery, Vol 48, Iss 1, Pp 1-8 (2019)
بيانات النشر: BMC, 2019.
سنة النشر: 2019
المجموعة: LCC:Surgery
مصطلحات موضوعية: Oropharyngeal cancer, HPV, Survival, Smoking, EGFR, Surgery, RD1-811
الوصف: Abstract Background This study aims to investigate EGFR as a prognostic biomarker in oropharyngeal squamous cell carcinoma (OPSCC). Methods OPSCC patients from retrospective (1998–2009) and prospective cohorts (2014–2017) were included. Retrospectively collected tumors were used to construct tissue microarrays (TMAs), which were stained with EGFR, p16, DAPI and Pan-cytokeratin, and digitally quantified. EGFR, CDKN2A and HPV E6/7 levels from prospectively collected OPSCC was measured by droplet digital PCR (ddPCR). Biomarkers were compared to patient covariates, factors and survival outcomes. Results A total of 249 patients were included retrospectively and 64 patients were enrolled prospectively. p16 status (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1916-0216
Relation: http://link.springer.com/article/10.1186/s40463-018-0323-6; https://doaj.org/toc/1916-0216
DOI: 10.1186/s40463-018-0323-6
URL الوصول: https://doaj.org/article/3c2dffc5747342128cfa0d496afe21e5
رقم الأكسشن: edsdoj.3c2dffc5747342128cfa0d496afe21e5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19160216
DOI:10.1186/s40463-018-0323-6