دورية أكاديمية
Morphometric analysis of the phrenic nerve in male and female Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
| العنوان: | Morphometric analysis of the phrenic nerve in male and female Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) |
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| المؤلفون: | A.R. Rodrigues, R.S. Ferreira, H.C. Salgado, V.P.S. Fazan |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 44, Iss 6, Pp 583-591 (2011) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Phrenic nerve, Sexual dimorphism, Morphometry, Spontaneously hypertensive rats, Wistar-Kyoto rats, Asymmetry, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Ventilatory differences between rat strains and genders have been described but the morphology of the phrenic nerve has not been investigated in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. A descriptive and morphometric study of the phrenic nerves of male (N = 8) and female (N = 9) SHR, and male (N = 5) and female (N = 6) WKY is presented. After arterial pressure and heart rate recordings, the phrenic nerves of 20-week-old animals were prepared for epoxy resin embedding and light microscopy. Morphometric analysis performed with the aid of computer software that took into consideration the fascicle area and diameter, as well as myelinated fiber profile and Schwann cell nucleus number per area. Phrenic nerves were generally larger in males than in females on both strains but larger in WKY compared to SHR for both genders. Myelinated fiber numbers (male SHR = 228 ± 13; female SHR = 258 ± 4; male WKY = 382 ± 23; female WKY = 442 ± 11 for proximal right segments) and density (N/mm²; male SHR = 7048 ± 537; female SHR = 10355 ± 359; male WKY = 9457 ± 1437; female WKY = 14351 ± 1448) for proximal right segments) were significantly larger in females of both groups and remarkably larger in WKY than SHR for both genders. Strain and gender differences in phrenic nerve myelinated fiber number are described for the first time in this experimental model of hypertension, indicating the need for thorough functional studies of this nerve in male and female SHR. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0100-879X 1414-431X |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000600012; https://doaj.org/toc/0100-879X; https://doaj.org/toc/1414-431X |
| URL الوصول: | https://doaj.org/article/e3c7c8e82f844a36aeb7a5656f28c54e |
| رقم الأكسشن: | edsdoj.3c7c8e82f844a36aeb7a5656f28c54e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 0100879X 1414431X |
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