دورية أكاديمية
Expression of the cellular prion protein by mast cells in the human carotid body
| العنوان: | Expression of the cellular prion protein by mast cells in the human carotid body |
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| المؤلفون: | Gregory D. Sweetland, Connor Eggleston, Jason C. Bartz, Candace K. Mathiason, Anthony E. Kincaid |
| المصدر: | Prion, Vol 17, Iss 1, Pp 67-74 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Biology (General) |
| مصطلحات موضوعية: | Carotid body, dorsal motor nucleus of the vagus, glossopharyngeal nerve, intermediolateral cell column, mast cell, neurofilament, Neurology. Diseases of the nervous system, RC346-429, Biology (General), QH301-705.5 |
| الوصف: | ABSTRACTPrion diseases are fatal neurologic disorders that can be transmitted by blood transfusion. The route for neuroinvasion following exposure to infected blood is not known. Carotid bodies (CBs) are specialized chemosensitive structures that detect the concentration of blood gasses and provide feedback for the neural control of respiration. Sensory cells of the CB are highly perfused and densely innervated by nerves that are synaptically connected to the brainstem and thoracic spinal cord, known to be areas of early prion deposition following oral infection. Given their direct exposure to blood and neural connections to central nervous system (CNS) areas involved in prion neuroinvasion, we sought to determine if there were cells in the human CB that express the cellular prion protein (PrPC), a characteristic that would support CBs serving as a route for prion neuroinvasion. We collected CBs from cadaver donor bodies and determined that mast cells located in the carotid bodies express PrPC and that these cells are in close proximity to blood vessels, nerves, and nerve terminals that are synaptically connected to the brainstem and spinal cord. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 19336896 1933-690X 1933-6896 |
| Relation: | https://doaj.org/toc/1933-6896; https://doaj.org/toc/1933-690X |
| DOI: | 10.1080/19336896.2023.2193128 |
| URL الوصول: | https://doaj.org/article/3c90af0db7c34e84b7ea33809ddecdfb |
| رقم الأكسشن: | edsdoj.3c90af0db7c34e84b7ea33809ddecdfb |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 19336896 1933690X |
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| DOI: | 10.1080/19336896.2023.2193128 |