دورية أكاديمية
Locally invasive recurrence or metastasis of pheochromocytoma into the liver?—clinicopathological challenges
| العنوان: | Locally invasive recurrence or metastasis of pheochromocytoma into the liver?—clinicopathological challenges |
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| المؤلفون: | Sarah S. Tang, James W. K. Lee, Sujith Wijerethne, Shridhar Ganpathi Iyer, Susan Hue, Nga Min En, Rajeev Parameswaran |
| المصدر: | World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-9 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Surgery LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Pheochromocytoma, Adrenalectomy, Radiotherapy, Chemotherapy, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Pheochromocytomas (PCC) are rare and functional neuroendocrine tumors developing from adrenal chromaffin cells. Predicting malignant behavior especially in the absence of metastasis can be quite challenging even in the era of improved understanding of the molecular mechanisms involved in PCCs. Currently, two histopathological grading systems Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and Grading of Adrenal Pheochromocytoma and Paraganglioma (GAPP) score are used in clinical practice, but these are subject to significant interobserver variability. Some of the most useful clinical factors associated with malignancy are large size ([4–5 cm), and genetic features such as presence of SDHB germline mutations. Local invasion is uncommon in PCC and metastasis seen in 10 to 17% but higher in germline mutations and when this occurs management can be challenging. Here, we report on a case with challenges faced by the pathologist and clinicians alike in diagnosis and management of PCC recurrence. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-7819 |
| Relation: | https://doaj.org/toc/1477-7819 |
| DOI: | 10.1186/s12957-022-02817-6 |
| URL الوصول: | https://doaj.org/article/3c96941312784999a87fd7cc0a23aebd |
| رقم الأكسشن: | edsdoj.3c96941312784999a87fd7cc0a23aebd |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14777819 |
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| DOI: | 10.1186/s12957-022-02817-6 |