دورية أكاديمية
Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes.
| العنوان: | Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes. |
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| المؤلفون: | Jana Drgonova, Josefin A Jacobsson, Joan C Han, Jack A Yanovski, Robert Fredriksson, Claude Marcus, Helgi B Schiöth, George R Uhl |
| المصدر: | PLoS ONE, Vol 8, Iss 9, p e68245 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Brain pathways, including those in hypothalamus and nucleus of the solitary tract, influence food intake, nutrient preferences, metabolism and development of obesity in ways that often differ between males and females. Branched chain amino acids, including leucine, can suppress food intake, alter metabolism and change vulnerability to obesity. The SLC6A15 (v7-3) gene encodes a sodium-dependent transporter of leucine and other branched chain amino acids that is expressed by neurons in hypothalamus and nucleus of the solitary tract. We now report that SLC6A15 knockout attenuates leucine's abilities to reduce both: a) intake of normal chow and b) weight gain produced by access to a high fat diet in gender-selective fashions. We identify SNPs in the human SLC6A15 that are associated with body mass index and insulin resistance in males. These observations in mice and humans support a novel, gender-selective role for brain amino acid compartmentalization mediated by SLC6A15 in diet and obesity-associated phenotypes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3762852?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0068245 |
| URL الوصول: | https://doaj.org/article/d3ca691d021a4d298989253ee80b807f |
| رقم الأكسشن: | edsdoj.3ca691d021a4d298989253ee80b807f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0068245 |