دورية أكاديمية
CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex
| العنوان: | CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex |
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| المؤلفون: | Kun Chen, Xi Chen, Chuandong Lang, Xingshi Yuan, Junming Huang, Zhi Li, Mingyou Xu, Kerong Wu, Chenhe Zhou, Qidong Li, Chen Zhu, Lianxin Liu, Xifu Shang |
| المصدر: | Experimental and Molecular Medicine, Vol 55, Iss 9, Pp 2051-2066 (2023) |
| بيانات النشر: | Nature Publishing Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Biochemistry |
| مصطلحات موضوعية: | Medicine, Biochemistry, QD415-436 |
| الوصف: | Abstract The identification of key regulatory factors that control osteoclastogenesis is important. Accumulating evidence indicates that circular RNAs (circRNAs) are discrete functional entities. However, the complexities of circRNA expression as well as the extent of their regulatory functions during osteoclastogenesis have yet to be revealed. Here, based on circular RNA sequencing data, we identified a circular RNA, circFam190a, as a critical regulator of osteoclast differentiation and function. During osteoclastogenesis, circFam190a is significantly upregulated. In vitro, circFam190a enhanced osteoclast formation and function. In vivo, overexpression of circFam190a induced significant bone loss, while knockdown of circFam190a prevented pathological bone loss in an ovariectomized (OVX) mouse osteoporosis model. Mechanistically, our data suggest that circFam90a enhances the binding of AKT1 and HSP90β, promoting AKT1 stability. Altogether, our findings highlight the critical role of circFam190a as a positive regulator of osteoclastogenesis, and targeting circFam190a might be a promising therapeutic strategy for treating pathological bone loss. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2092-6413 |
| Relation: | https://doaj.org/toc/2092-6413 |
| DOI: | 10.1038/s12276-023-01085-y |
| URL الوصول: | https://doaj.org/article/3cb29d8e8aef4dad88abef4349cf2023 |
| رقم الأكسشن: | edsdoj.3cb29d8e8aef4dad88abef4349cf2023 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20926413 |
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| DOI: | 10.1038/s12276-023-01085-y |