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Effect of a High-Protein High-Fibre Nutritional Supplement on Lipid Profile in Overweight/Obese Adults with Type 2 Diabetes Mellitus: A 24-Week Randomized Controlled Trial

التفاصيل البيبلوغرافية
العنوان: Effect of a High-Protein High-Fibre Nutritional Supplement on Lipid Profile in Overweight/Obese Adults with Type 2 Diabetes Mellitus: A 24-Week Randomized Controlled Trial
المؤلفون: Rachana Bhoite, Anitha Chandrasekaran, Varalakshmi Lalithya Pratti, Vinita Satyavrat, Shivani Aacharya, Amey Mane, Suyog Mehta, Ravindra Machhindra Kale, Gayathri Nagamuthu, Sasikala Selvaraj, Gayathri Rajagopal, Sudha Vasudevan, Shobana Shanmugam, Anjana Ranjit Mohan, Ranjit Unnikrishnan, Kamala Krishnaswamy, Viswanathan Mohan
المصدر: Journal of Nutrition and Metabolism, Vol 2021 (2021)
بيانات النشر: Wiley, 2021.
سنة النشر: 2021
المجموعة: LCC:Nutritional diseases. Deficiency diseases
مصطلحات موضوعية: Nutritional diseases. Deficiency diseases, RC620-627
الوصف: Background. Foods rich in protein and dietary fibre could potentially improve lipid profile in overweight or obese diabetic patients with dyslipidemia and, thereby, mitigate their risk of cardiovascular disease (CVD). In this study, the effect of providing high-protein high-fibre (HPHF) nutritional supplement in addition to standard care of type 2 diabetes mellitus (T2DM) on lipid profile was evaluated. Methods. In this open-label, parallel-arm, prospective, randomized study, a total of 100 overweight/obese participants with T2DM were randomized to either an intervention group (25 g HPHF nutritional supplement given twice daily along with a standard care of T2DM) or a control group (standard care of T2DM) for 24 weeks. Change from baseline in lipid parameters such as total cholesterol (TChol), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) was assessed between the intervention and control group at week 12 and week 24. Participant compliance was assessed using the dietary 24-hour recall. Statistical analysis was performed to assess the main effects on within- and between-group changes from baseline to end of 24 weeks. Results. Participants in the HPHF nutritional supplement group showed a statistically significant improvement in HDL-C levels by the end of 24 weeks (p=0.04) and a significant increase in protein and total dietary fibre intake (p=0.002 and p=0.00, respectively) compared to the control group. The TChol/HDL-C ratio was significantly lower (p=0.03) in the HPHF group from baseline to 24 weeks. Conclusion. Twice-daily consumption of a HPHF nutritional supplement significantly improved HDL-C levels. Inclusion of the HPHF supplement would be a useful effective aid for managing dyslipidemia in overweight/obese individuals with T2DM.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2090-0724
2090-0732
Relation: https://doaj.org/toc/2090-0724; https://doaj.org/toc/2090-0732
DOI: 10.1155/2021/6634225
URL الوصول: https://doaj.org/article/c3cbc729617e4497bbe58eb494e379d0
رقم الأكسشن: edsdoj.3cbc729617e4497bbe58eb494e379d0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20900724
20900732
DOI:10.1155/2021/6634225