دورية أكاديمية
Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome
| العنوان: | Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome |
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| المؤلفون: | Soyoung Park, Hye Eun Kwon, Chung Mo Koo, Yun Jung Hur, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim |
| المصدر: | Annals of Child Neurology, Vol 32, Iss 1, Pp 13-20 (2024) |
| بيانات النشر: | Korean Child Neurology Society, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Internal medicine LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | child, lennox gastaut syndrome, seizures, Internal medicine, RC31-1245, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Purpose This study examined the characteristics and outcomes of resective epilepsy surgery following corpus callosotomy (CC) in children with Lennox-Gastaut syndrome (LGS). Methods We retrospectively analyzed 17 children with LGS who underwent resective surgery (RS) after CC over a span of 10 years, with a minimum of 2 years of follow-up, at a single tertiary epilepsy center in Korea. Results Of the 17 patients, 13 (73.5%) demonstrated favorable surgical outcomes (Engel class I or II) at 1 year after RS, and eight (47.1%) were ultimately free of seizures 2 years after surgery. A significantly larger decrease in the number of anti-seizure medications taken from before to 2 years after the final surgical procedure was observed in the group that became seizure-free than in the group with persistent seizures (P=0.062). Furthermore, a significantly greater decline in daily adaptive function was found in the persistent seizure group (P=0.059). The baseline characteristics, results of presurgical evaluation, and treatment-related factors assessed prior to surgery showed no significant differences between the seizure-free group and the group with persistent seizures. Conclusion In conclusion, RS may be a viable option for patients with LGS who exhibit lateralization and/or localization on presurgical evaluation after CC, as the procedure may reveal a concealed primary focus. The proactive implementation of two-stage epilepsy surgery could provide significant seizure reduction and preservation of cognitive function in carefully selected patients with LGS. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2635-909X 2635-9103 |
| Relation: | http://annchildneurol.org/upload/pdf/acn-2023-00164.pdf; https://doaj.org/toc/2635-909X; https://doaj.org/toc/2635-9103 |
| DOI: | 10.26815/acn.2023.00164 |
| URL الوصول: | https://doaj.org/article/3d103029c19242229177680e3e4c018f |
| رقم الأكسشن: | edsdoj.3d103029c19242229177680e3e4c018f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2635909X 26359103 |
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| DOI: | 10.26815/acn.2023.00164 |