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Posaconazole as rescue therapy in African histoplasmosis

التفاصيل البيبلوغرافية
العنوان: Posaconazole as rescue therapy in African histoplasmosis
المؤلفون: Daniel Gonçalves, Catarina Ferraz, Luisa Vaz
المصدر: Brazilian Journal of Infectious Diseases, Vol 17, Iss 1, Pp 102-105 (2013)
بيانات النشر: Elsevier, 2013.
سنة النشر: 2013
المجموعة: LCC:Infectious and parasitic diseases
LCC:Microbiology
مصطلحات موضوعية: Posaconazole, Histoplasmosis, Salvage therapy, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
الوصف: Posaconazole Histoplasmosis Salvage therapy African histoplasmosis is a granulomatous mycosis caused by Histoplasma capsulatum var. duboisii. Treatment is usually extrapolated from guidelines for classical histoplasmosis, and includes 2-4 weeks of amphotericin B followed by a step-down maintenance therapy with itraconazole. Pediatric usage of posaconazole, an oral second-generation azole, remains off-label, but recent surveys show that it is safe and well tolerated in children. We report a case of disseminated African histoplasmosis in a 12-year-old boy from Guinea-Bissau. Therapy with amphotericin B and itraconazole led to a progressive clinical deterioration. A dramatic and lasting improvement was observed using posaconazole. He completed 12 months of therapy. No relapse was noted during or 3 months after treatment. We report that posaconazole may be a safe and efficacious drug in the salvage management of disseminated AH, either in patients with disease refractory to conventional anti-fungal therapy, or in patients whose serious adverse effects of first-line drugs preclude its use.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1413-8670
1678-4391
Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100018; https://doaj.org/toc/1413-8670; https://doaj.org/toc/1678-4391
URL الوصول: https://doaj.org/article/ce3d126d733b4bba99bde56322204691
رقم الأكسشن: edsdoj.3d126d733b4bba99bde56322204691
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14138670
16784391