دورية أكاديمية
The effect of plasma cortisol on hippocampal atrophy and clinical progression in mild cognitive impairment
| العنوان: | The effect of plasma cortisol on hippocampal atrophy and clinical progression in mild cognitive impairment |
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| المؤلفون: | Silke White, René Mauer, Catharina Lange, Olga Klimecki, Willem Huijbers, Miranka Wirth, for the Alzheimer's Disease Neuroimaging Initiative |
| المصدر: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 3, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Geriatrics |
| مصطلحات موضوعية: | ADNI, cortisol, hippocampus, hypothalamic‐pituitary‐adrenal axis, MCI, neurodegeneration, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Abstract Introduction Both elevated cortisol and hippocampal volume have been linked to an increased risk for the development of Alzheimer's disease (AD). This longitudinal study assessed the effects of plasma cortisol on hippocampal atrophy and clinical progression rates in patients with mild cognitive impairment (MCI). Methods Patients with amnestic MCI (n = 304) were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) based on availability of baseline plasma cortisol and hippocampal volume measures, assessed at baseline and during follow‐ups. We investigated associations between plasma cortisol, hippocampal volume, and risk of clinical progression to AD over a study period of up to 100 months (mean follow‐up time 36.8 months) using linear mixed models, Cox proportional hazards models, and Kaplan‐Meier estimators. Results Plasma cortisol predicted greater hippocampal atrophy, such that participants with higher cortisol showed faster decline in hippocampal volume over time (interaction: β = ‐0.15, p = 0.004). Small hippocampal volume predicted a higher risk of clinical progression to AD (haard ratio [HR] = 2.15; confidence in terval [CI], 1.64–2.80; p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-8729 19966024 |
| Relation: | https://doaj.org/toc/2352-8729 |
| DOI: | 10.1002/dad2.12463 |
| URL الوصول: | https://doaj.org/article/3d94e199660246ee8775f780d16360fd |
| رقم الأكسشن: | edsdoj.3d94e199660246ee8775f780d16360fd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23528729 19966024 |
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| DOI: | 10.1002/dad2.12463 |