دورية أكاديمية
The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy
العنوان: | The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy |
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المؤلفون: | Toka A. Ahmed, Bassant Eldaly, Shadwa Eldosuky, Hoda Elkhenany, Azza M. El-Derby, Muhamed F. Elshazly, Nagwa El-Badri |
المصدر: | Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023) |
بيانات النشر: | BMC, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Medicine (General) LCC:Biochemistry |
مصطلحات موضوعية: | COVID-19, Lung organoid, Synthetic polymers, Lung spheroid, Natural polymers, Medicine (General), R5-920, Biochemistry, QD415-436 |
الوصف: | Abstract Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine development. Current experimentation on traditional two-dimensional culture (2D) fails to accurately mimic the in vivo microenvironment for the disease, while in vivo animal model testing does not faithfully replicate human COVID-19 infection. Human-based three-dimensional (3D) cell culture models such as spheroids, organoids, and organ-on-a-chip present a promising solution to these challenges. In this report, we review the recent 3D in vitro lung models used in COVID-19 infection and drug screening studies and highlight the most common types of natural and synthetic polymers used to generate 3D lung models. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1757-6512 |
Relation: | https://doaj.org/toc/1757-6512 |
DOI: | 10.1186/s13287-023-03341-4 |
URL الوصول: | https://doaj.org/article/3daf7c1f360a4bcd9526f64369598709 |
رقم الأكسشن: | edsdoj.3daf7c1f360a4bcd9526f64369598709 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 17576512 |
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DOI: | 10.1186/s13287-023-03341-4 |