دورية أكاديمية
أعرض في EDS

The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy

التفاصيل البيبلوغرافية
العنوان: The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy
المؤلفون: Toka A. Ahmed, Bassant Eldaly, Shadwa Eldosuky, Hoda Elkhenany, Azza M. El-Derby, Muhamed F. Elshazly, Nagwa El-Badri
المصدر: Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine (General)
LCC:Biochemistry
مصطلحات موضوعية: COVID-19, Lung organoid, Synthetic polymers, Lung spheroid, Natural polymers, Medicine (General), R5-920, Biochemistry, QD415-436
الوصف: Abstract Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine development. Current experimentation on traditional two-dimensional culture (2D) fails to accurately mimic the in vivo microenvironment for the disease, while in vivo animal model testing does not faithfully replicate human COVID-19 infection. Human-based three-dimensional (3D) cell culture models such as spheroids, organoids, and organ-on-a-chip present a promising solution to these challenges. In this report, we review the recent 3D in vitro lung models used in COVID-19 infection and drug screening studies and highlight the most common types of natural and synthetic polymers used to generate 3D lung models.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1757-6512
Relation: https://doaj.org/toc/1757-6512
DOI: 10.1186/s13287-023-03341-4
URL الوصول: https://doaj.org/article/3daf7c1f360a4bcd9526f64369598709
رقم الأكسشن: edsdoj.3daf7c1f360a4bcd9526f64369598709
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17576512
DOI:10.1186/s13287-023-03341-4