دورية أكاديمية
D-dimer: A Marker of Severity in COVID-19
| العنوان: | D-dimer: A Marker of Severity in COVID-19 |
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| المؤلفون: | B Saravanan, S Vasuki, BM Pabithadevi, M Saradha, R Raskin Erusan, S Alagesan, Shantaraman Kalyanaraman |
| المصدر: | Journal of Clinical and Diagnostic Research, Vol 14, Iss 11, Pp BC10-BC14 (2020) |
| بيانات النشر: | JCDR Research and Publications Private Limited, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | endothelial dysfunction, factor xiiia, fibrinogen, severity, Medicine |
| الوصف: | Introduction: The ever-growing number of COVID-19 patients stresses upon the need to identify effective yet readily available predictors of disease severity to ensure better clinical outcomes. D-dimer is a fibrin specific degradation product derived by enzymatic action of plasmin on factor XIIIa cross-linked fibrin. It serves as an ideal marker for activation of coagulation and fibrinolytic pathways. Identification of coagulopathy as an important complication in COVID-19 patients has brought to focus D-dimer as a possible predictor of clinical severity in patients. Aim: In this study, we analysed the role of D-dimer levels in assessing the clinical severity of the COVID-19 patients. Materials and Methods: We enrolled 217 in-patients of Tirunelveli Medical College in this single centre observational study and classified them into asymptomatic, mild, moderate and severe according to “Clinical Management Protocol: COVID 19”, by the Ministry of Health and Family Welfare and Director General of Health Services. D-dimer was estimated in the separated plasma, using latex based assay using semi-automated coagulation analyser. Data were presented as percentages for categorical variables and median±Inter Quartile Range (IQR) for continuous variables. Chi-square test was used to compare the D-dimer values between symptomatic and asymptomatic groups. A value of p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2249-782X 0973-709X |
| Relation: | https://jcdr.net/articles/PDF/14302/46246_CE[Ra1]_F(SL)_PF1_(SY_OM)_PN(SL).pdf; https://doaj.org/toc/2249-782X; https://doaj.org/toc/0973-709X |
| DOI: | 10.7860/JCDR/2020/46246.14302 |
| URL الوصول: | https://doaj.org/article/3e03cc3b3a5e4f179df5e8ee265d0ebe |
| رقم الأكسشن: | edsdoj.3e03cc3b3a5e4f179df5e8ee265d0ebe |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2249782X 0973709X |
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| DOI: | 10.7860/JCDR/2020/46246.14302 |