دورية أكاديمية
Intra coronary freshly isolated bone marrow cells transplantation improve cardiac function in patients with ischemic heart disease
| العنوان: | Intra coronary freshly isolated bone marrow cells transplantation improve cardiac function in patients with ischemic heart disease |
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| المؤلفون: | Bozdag-Turan Ilkay, Goekmen Turan R, Ludovicy Sophie, Akin Ibrahim, Kische Stephan, Schneider Henrik, Rehders Tim C, Turan C, Arsoy Nicole S, Hermann Tina, Paranskaya Liliya, Ortak Jasmin, Kohlschein Peter, Bastian Manuela, Sahin Kurtulus, Nienaber Christoph A, Ince Hueseyin |
| المصدر: | BMC Research Notes, Vol 5, Iss 1, p 195 (2012) |
| بيانات النشر: | BMC, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine LCC:Biology (General) LCC:Science (General) |
| مصطلحات موضوعية: | Ischemic heart disease, Freshly isolated bone marrow cell transplantation, Global EF, Infarct size, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390 |
| الوصف: | Abstract Background Autologous bone marrow cell transplantation (BMCs-Tx) is a promising novel option for treatment of cardiovascular disease. In this study we analyzed whether intracoronary autologous freshly isolated BMCs-Tx have beneficial effects on cardiac function in patients with ischemic heart disease (IHD). Results In this prospective nonrandomized study we treated 12 patients with IHD by freshly isolated BMCs-Tx by use of point of care system and compared them with a representative 12 control group without cell therapy. Global ejection fraction (EF) and infarct size area were determined by left ventriculography. Intracoronary transplantation of autologous freshly isolated BMCs led to a significant reduction of infarct size (p Conclusions These results demonstrate that intracoronary transplantation of autologous freshly isolated BMCs by use of point of care system is safe and may lead to improvement of cardiac function in patients with IHD. Trial registration Registration number: ISRCTN54510226 |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-0500 |
| Relation: | http://www.biomedcentral.com/1756-0500/5/195; https://doaj.org/toc/1756-0500 |
| DOI: | 10.1186/1756-0500-5-195 |
| URL الوصول: | https://doaj.org/article/3e096e99255d42c992eafc6827f95d1c |
| رقم الأكسشن: | edsdoj.3e096e99255d42c992eafc6827f95d1c |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17560500 |
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| DOI: | 10.1186/1756-0500-5-195 |