دورية أكاديمية
Exhaled nitric oxide in acute exacerbation of pediatric asthma
| العنوان: | Exhaled nitric oxide in acute exacerbation of pediatric asthma |
|---|---|
| المؤلفون: | Ratnawati Ratnawati, V Nguyen, J Morton, R L Henry, P S Thomas |
| المصدر: | Paediatrica Indonesiana, Vol 48, Iss 2, Pp 64-70 (2008) |
| بيانات النشر: | Indonesian Pediatric Society Publishing House, 2008. |
| سنة النشر: | 2008 |
| المجموعة: | LCC:Medicine LCC:Pediatrics |
| مصطلحات موضوعية: | exhaled nitric oxide, asthma exacerbations, eosinophils, FEV1, Medicine, Pediatrics, RJ1-570 |
| الوصف: | Background Measurement of exhaled nitric oxide (eNO) is a non- invasive and easy method to monitor airway inflammation. Objectives To compare the levels of eNO during and after an exacerbation of asthma, to evaluate the effect of glucocor- ticosteroids (GCS) on the levels of eNO and to correlate eNO with other markers of inflammation such as symptom scores, FEV 1 and sputum eosinophils. Methods The observational study was performed over 24 months at a tertiary paediatric hospital. Subjects underwent eNO measurement, spirometry and sputum induction during an asthma exacerbation and then two weeks later. A symptom score was recorded everyday for two weeks. All subjects were treated with ß 2 -adrenergic agonists and an oral glucocorticosteroid (GCS). Results Fifteen subjects with acute asthma exacerbation aged 5 and 16 years old participated in the study. The mean level of eNO during the acute exacerbation was significantly higher than eNO levels at the follow-up visit, 11.2 (95%CI 9.2;13.2) vs. 8.0 (95%CI 5.0;11.1) ppb, P=0.03. In the acute exacerbation, eNO correlated with sputum eosinophils (P=0.04), but no correlation could be found between eNO and the other markers of inflammation during exacerbation or follow up. Conclusions eNO level increased during asthma exacerbation and decreased after two weeks of glucocorticosteroid therapy. Measurement of eNO is a practical monitoring method in emergency management of asthmatic children. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0030-9311 2338-476X |
| Relation: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/480; https://doaj.org/toc/0030-9311; https://doaj.org/toc/2338-476X |
| DOI: | 10.14238/pi48.2.2008.64-70 |
| URL الوصول: | https://doaj.org/article/3eb052a9be4e47eaa12ebb4ce94c0b94 |
| رقم الأكسشن: | edsdoj.3eb052a9be4e47eaa12ebb4ce94c0b94 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00309311 2338476X |
|---|---|
| DOI: | 10.14238/pi48.2.2008.64-70 |