دورية أكاديمية
Atherogenic Index of Plasma (AIP) and Its Association with Fatty Liver in Obese Adolescents
| العنوان: | Atherogenic Index of Plasma (AIP) and Its Association with Fatty Liver in Obese Adolescents |
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| المؤلفون: | Hüseyin Dağ, Fatih İncirkuş, Okan Dikker |
| المصدر: | Children, Vol 10, Iss 4, p 641 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Pediatrics |
| مصطلحات موضوعية: | atherogenic index of plasma, fatty liver, obesity, vitamin D, Pediatrics, RJ1-570 |
| الوصف: | Background: The atherogenic index of plasma (AIP) is the base-10 logarithmic conversion of the triglyceride to high-density lipoprotein cholesterol ratio [AIP = log10 (triglyceride/HDL cholesterol)]. Some studies have found a link between low serum vitamin D levels, AIP, and fatty liver. This study was conducted to evaluate the relationship between AIP levels, fatty liver, and vitamin D levels in obese adolescents aged 10–17 years. Methods: This study included 136 adolescents, including 83 obese and 53 healthy controls, in the age range of 10–17 years. Thirty-nine of the obese adolescents had fatty livers. Those with ultrasonography grades 2 or 3 of fat were in the fatty liver group. The AIP value was calculated as the logarithmic conversion of the ratio (triglyceride/HDL cholesterol) at the base of 10. Vitamin D and other laboratory tests were analyzed biochemically. Statistical evaluations were made with the SPSS program. Results: The AIP, body mass index (BMI), homeostatic model assessment for insulin resistance (HOMA-IR), and insulin averages of obese adolescents with fatty liver were significantly higher than those of obese adolescents without fatty liver and the healthy control group (p < 0.05). Again, the mean AIP of obese patients without fatty liver was pointedly higher than that of the healthy control group (p < 0.05). There was a positive, moderate relationship between AIP and BMI, AIP and HOMA-IR, and AIP and insulin levels (p < 0.05), whereas there was a negative, moderate (37.3%) relationship between AIP and vitamin D (p = 0.019). Conclusion: AIP levels were higher in obese adolescents, and this increase was higher in obese adolescents with fatty liver in this study. Moreover, we detected a negative correlation between AIP and vitamin D levels and a positive correlation with BMI, insulin resistance, and insulin levels. Based on our data, we concluded that AIP can be a useful predictor of fatty liver in obese adolescents. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 10040641 2227-9067 |
| Relation: | https://www.mdpi.com/2227-9067/10/4/641; https://doaj.org/toc/2227-9067 |
| DOI: | 10.3390/children10040641 |
| URL الوصول: | https://doaj.org/article/d3eb3486456e4219b8accb020c721ca0 |
| رقم الأكسشن: | edsdoj.3eb3486456e4219b8accb020c721ca0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10040641 22279067 |
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| DOI: | 10.3390/children10040641 |