دورية أكاديمية
MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1.
| العنوان: | MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1. |
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| المؤلفون: | Zhu-mei Shi, Jing Wang, Zhiping Yan, Yong-ping You, Chong-yong Li, Xu Qian, Yu Yin, Peng Zhao, Ying-ying Wang, Xie-feng Wang, Ming-na Li, Ling-Zhi Liu, Ning Liu, Bing-Hua Jiang |
| المصدر: | PLoS ONE, Vol 7, Iss 3, p e32709 (2012) |
| بيانات النشر: | Public Library of Science (PLoS), 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-128 expression levels were decreased in glioma, and identified p70S6K1 as a novel direct target of miR-128. Overexpression of miR-128 suppressed p70S6K1 and its downstream signaling molecules such as HIF-1 and VEGF expression, and attenuated cell proliferation, tumor growth and angiogenesis. Forced expression of p70S6K1 can partly rescue the inhibitory effect of miR-128 in the cells. Taken together, these findings will shed light to the role and mechanism of miR-128 in regulating glioma tumor angiogenesis via miR-128/p70S6K1 axis, and miR-128 may serve as a potential therapeutic target in glioma in the future. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3307714?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0032709 |
| URL الوصول: | https://doaj.org/article/3f03eb1c8f274805a7bff8f2d0dc172f |
| رقم الأكسشن: | edsdoj.3f03eb1c8f274805a7bff8f2d0dc172f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0032709 |