دورية أكاديمية
The modulatory action of C-Vx substance on the immune system in COVID-19
| العنوان: | The modulatory action of C-Vx substance on the immune system in COVID-19 |
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| المؤلفون: | Ilhan Tahrali, Nilgun Akdeniz, Vuslat Yilmaz, Umut C. Kucuksezer, Fatma B. Oktelik, Ozkan Ozdemir, Esin Cetin-Aktas, Yelda Ogutmen, Arzu Ergen, Neslihan Abaci, Erdem Tuzun, Oral Oncul, Gunnur Deniz |
| المصدر: | Emerging Microbes and Infections, Vol 11, Iss 1, Pp 2698-2710 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| مصطلحات موضوعية: | C-Vx, COVID-19, cytokines, cytotoxicity, immune system, inflammation, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| الوصف: | The modulatory effect of C-Vx, a novel therapeutic agent, on the immune system of COVID-19 patients was investigated. The functions of T and NK cells of COVID-19 patients with different disease severity were evaluated by flow cytometry in response to C-Vx stimulation. The levels of pro- and anti-inflammatory cytokines were detected by multiplex assay in supernatants after cell culture with C-Vx. Bradykinin, IRF3, and IFN-α levels were also measured by ELISA in the presence or absence of C-Vx stimulation. As a result, increased CD107a expression was observed on NK cells in response to C-Vx addition. The proliferation of T cell subsets was increased by C-Vx, decreasing by disease severity. IL-4 and IL-10 levels were elevated while IFN-γ and IL-17 levels were reduced in T cells following C-Vx stimulation. However, the levels of pro-inflammatory IL-1β, IL-6, IL-8, IFN-γ and GM-CSF were significantly increased upon C-Vx stimulation. IFN-α levels tended to increase after incubation with C-Vx. These findings support an immunomodulatory action of C-Vx on the immune system of patients with a mild and moderate phase of COVID-19. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 22221751 2222-1751 |
| Relation: | https://doaj.org/toc/2222-1751 |
| DOI: | 10.1080/22221751.2022.2125347 |
| URL الوصول: | https://doaj.org/article/a3f280e2158e4a97a3fb68af30eb1231 |
| رقم الأكسشن: | edsdoj.3f280e2158e4a97a3fb68af30eb1231 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 22221751 |
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| DOI: | 10.1080/22221751.2022.2125347 |