دورية أكاديمية
The bio-distribution, clearance pathways, and toxicity mechanisms of ambient ultrafine particles
| العنوان: | The bio-distribution, clearance pathways, and toxicity mechanisms of ambient ultrafine particles |
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| المؤلفون: | Dongyang Han, Renjie Chen, Haidong Kan, Yanyi Xu |
| المصدر: | Eco-Environment & Health, Vol 2, Iss 3, Pp 95-106 (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Ecology LCC:Environmental sciences |
| مصطلحات موضوعية: | Ambient ultrafine particles, Bio-distribution of particles, Clearance pathways, Toxicity mechanisms, Ecology, QH540-549.5, Environmental sciences, GE1-350 |
| الوصف: | Ambient particles severely threaten human health worldwide. Compared to larger particles, ultrafine particles (UFPs) are highly concentrated in ambient environments, have a larger specific surface area, and are retained for a longer time in the lung. Recent studies have found that they can be transported into various extra-pulmonary organs by crossing the air-blood barrier (ABB). Therefore, to understand the adverse effects of UFPs, it is crucial to thoroughly investigate their bio-distribution and clearance pathways in vivo after inhalation, as well as their toxicological mechanisms. This review highlights emerging evidence on the bio-distribution of UFPs in pulmonary and extra-pulmonary organs. It explores how UFPs penetrate the ABB, the blood-brain barrier (BBB), and the placental barrier (PB) and subsequently undergo clearance by the liver, kidney, or intestine. In addition, the potential underlying toxicological mechanisms of UFPs are summarized, providing fundamental insights into how UFPs induce adverse health effects. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2772-9850 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S277298502300025X; https://doaj.org/toc/2772-9850 |
| DOI: | 10.1016/j.eehl.2023.06.001 |
| URL الوصول: | https://doaj.org/article/d3f69dd4d757439697c03fbfbc21aa9c |
| رقم الأكسشن: | edsdoj.3f69dd4d757439697c03fbfbc21aa9c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 27729850 |
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| DOI: | 10.1016/j.eehl.2023.06.001 |