دورية أكاديمية
Impact of direct acting antiviral agents on kidney function in hepatitis C virus infected patients with chronic kidney disease
| العنوان: | Impact of direct acting antiviral agents on kidney function in hepatitis C virus infected patients with chronic kidney disease |
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| المؤلفون: | Wedad Adel Mahmoud, Iman Ibrahim Sarhan, Osama Mahmoud Mohamed, Hayam Ahmed Hebah, Ossama Ashraf Ahmed, Lina Essam Khedr |
| المصدر: | Journal of Nephropathology, Vol 10, Iss 3, Pp e29-e29 (2021) |
| بيانات النشر: | Society of Diabetic Nephropathy Prevention, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Pathology LCC:Internal medicine LCC:Other systems of medicine |
| مصطلحات موضوعية: | direct-acting antiviral, hepatitis c virus, chronic kidney disease, cryoglobulinemia, end-stage renal disease, Pathology, RB1-214, Internal medicine, RC31-1245, Other systems of medicine, RZ201-999 |
| الوصف: | Introduction: Hepatitis C virus (HCV) infection is strongly associated with chronic kidney disease (CKD). It is an independent risk factor for developing CKD and significantly increases morbidity and mortality in CKD patients. Treatment with newer direct-acting antiviral (DAA) regimens in patients with CKD is showing conflicting results as regards safety and efficacy. Objectives: To evaluate the safety and efficacy of DAAs and their impact on kidney function in CKD patients. Patients and Methods: We conducted a prospective observational study on 100 CKD patients stages 3-4, receiving treatment for HCV at MASRI (Faculty of Medicine Ain Shams University Research Institute), with two different DAAs regimens (sofosbuvir/daclatasvir with or without ribavirin and ombitasvir/paritaprevir/ritonavir [OMV/PTV/RTV] with ribavirin), completed over six months follow up. Serum creatinine, estimated glomerular filtration rate (eGFR), and proteinuria were followed during and after treatment. Results: Sustained virological response (SVR) was achieved in all patients. Improvement of eGFR (8-15 mL/min/1.73 m2) and proteinuria was found in both study groups. Acute kidney injury (AKI) was uncommon; it occurred in three (3%) patients, out of them, two patients showed complete recovery. Adverse events were common (43%), but serious adverse events were uncommon (2%). Conclusion: DAA regimens were effective and well-tolerated for HCV infected patients with stage 3-4 CKD, where viral clearance caused improvement in eGFR and proteinuria. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2251-8363 2251-8819 |
| Relation: | https://nephropathol.com/PDF/jnp-10-e29.pdf; https://doaj.org/toc/2251-8363; https://doaj.org/toc/2251-8819 |
| DOI: | 10.34172/jnp.2021.29 |
| URL الوصول: | https://doaj.org/article/d3f7df1953454b9497e18a52d97eb7f0 |
| رقم الأكسشن: | edsdoj.3f7df1953454b9497e18a52d97eb7f0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22518363 22518819 |
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| DOI: | 10.34172/jnp.2021.29 |