دورية أكاديمية
A dynamic model of lignin biosynthesis in Brachypodium distachyon
العنوان: | A dynamic model of lignin biosynthesis in Brachypodium distachyon |
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المؤلفون: | Mojdeh Faraji, Luis L. Fonseca, Luis Escamilla-Treviño, Jaime Barros-Rios, Nancy L. Engle, Zamin K. Yang, Timothy J. Tschaplinski, Richard A. Dixon, Eberhard O. Voit |
المصدر: | Biotechnology for Biofuels, Vol 11, Iss 1, Pp 1-13 (2018) |
بيانات النشر: | BMC, 2018. |
سنة النشر: | 2018 |
المجموعة: | LCC:Fuel LCC:Biotechnology |
مصطلحات موضوعية: | Brachypodium distachyon, Medicago truncatula, Panicum virgatum, Pathway analysis, Populus trichocarpa, Recalcitrance, Fuel, TP315-360, Biotechnology, TP248.13-248.65 |
الوصف: | Abstract Background Lignin is a crucial molecule for terrestrial plants, as it offers structural support and permits the transport of water over long distances. The hardness of lignin reduces plant digestibility by cattle and sheep; it also makes inedible plant materials recalcitrant toward the enzymatic fermentation of cellulose, which is a potentially valuable substrate for sustainable biofuels. Targeted attempts to change the amount or composition of lignin in relevant plant species have been hampered by the fact that the lignin biosynthetic pathway is difficult to understand, because it uses several enzymes for the same substrates, is regulated in an ill-characterized manner, may operate in different locations within cells, and contains metabolic channels, which the plant may use to funnel initial substrates into specific monolignols. Results We propose a dynamic mathematical model that integrates various datasets and other information regarding the lignin pathway in Brachypodium distachyon and permits explanations for some counterintuitive observations. The model predicts the lignin composition and label distribution in a BdPTAL knockdown strain, with results that are quite similar to experimental data. Conclusion Given the present scarcity of available data, the model resulting from our analysis is presumably not final. However, it offers proof of concept for how one may design integrative pathway models of this type, which are necessary tools for predicting the consequences of genomic or other alterations toward plants with lignin features that are more desirable than in their wild-type counterparts. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1754-6834 |
Relation: | http://link.springer.com/article/10.1186/s13068-018-1241-6; https://doaj.org/toc/1754-6834 |
DOI: | 10.1186/s13068-018-1241-6 |
URL الوصول: | https://doaj.org/article/3f86b4becd664e67b04f91dbfc7580c2 |
رقم الأكسشن: | edsdoj.3f86b4becd664e67b04f91dbfc7580c2 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 17546834 |
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DOI: | 10.1186/s13068-018-1241-6 |