دورية أكاديمية
Carotid Intima-Media Thickness and Anti-Phospholipid Antibodies in Patients with Systemic Lupus Erythematosus
| العنوان: | Carotid Intima-Media Thickness and Anti-Phospholipid Antibodies in Patients with Systemic Lupus Erythematosus |
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| المؤلفون: | C. Rollino, C. Massara, L. Besso, C. Marcuccio, M. Manganaro, T. Bertero, B. Montaruli, G. Beltrame, M. Ferro, G. Quattrocchio, F. Elia, F. Quarello |
| المصدر: | European Journal of Inflammation, Vol 7 (2009) |
| بيانات النشر: | SAGE Publishing, 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | An increase in mortality due to accelerated atherosclerosis has been reported in patients affected with Systemic Lupus Erythematosus (SLE). Anti-phospholipid antibodies (aPA) may play a pathogenetic role in the development of atherosclerosis. We measured carotid intima-media thickness (IMT), as a surrogate parameter of atherosclerosis, by B-mode ultrasound examination in 42 patients affected with SLE (11 men and 31 women) and in 42 healthy age- and sex-matched subjects. Lupus Anticoagulant (LA) (APTT sensitive, silica clotting time, DRVVT), Anti-cardiolipin antibodies (ACA) IgG and IgM, anti-β2glycoprotein 1 (anti-β2GP1) IgG and IgM and anti-prothrombin (anti-PT) IgG and IgM in ELISA (Orgentec Bouty) were also detected. IMT was 0.538±0.128 mm (0.310–0.866 mm) in SLE vs 0.473±0.084 mm in healthy subjects (-p 0.003–). IMT correlated with patients’ age (p0.600 mm and 33.3% in those with IMT 0.600 mm and 23.3% in patients with IMT 0.7 mm, 2 had LA positivity (40%) vs 10/37 (27%) of those with minor carotid thickness. In conclusion, IMT, a surrogate parameter of atherosclerosis, was correlated with Patients’ age and CRP and not with presence of aPA, even though, in the group of patients with greater IMT, there was a non-significant higher proportion of positivity for anti-phospholipid antibodies, in particular for Lupus Anticoagulant. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1721-727X 1721727X |
| Relation: | https://doaj.org/toc/1721-727X |
| DOI: | 10.1177/1721727X0900700103 |
| URL الوصول: | https://doaj.org/article/d3f8f3291ed64afa9c74a00d15e583ab |
| رقم الأكسشن: | edsdoj.3f8f3291ed64afa9c74a00d15e583ab |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1721727X |
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| DOI: | 10.1177/1721727X0900700103 |