دورية أكاديمية
Heart Uptake of [18F]Fluoro-4-Thia-Oleate in a Non-Alcoholic Fatty Liver Disease Mouse Model
| العنوان: | Heart Uptake of [18F]Fluoro-4-Thia-Oleate in a Non-Alcoholic Fatty Liver Disease Mouse Model |
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| المؤلفون: | Junfeng Li, Weidong Hu, Jiangling Peng, Patty Wong, Fouad Kandeel, Tove Olafsen, John E. Shively |
| المصدر: | Pharmaceuticals, Vol 15, Iss 12, p 1577 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | non-alcoholic fatty liver disease, CEACAM1, [18]F-fluoro-4-thia-oleate, PET/MRI, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | The world-wide high incidence of non-alcoholic fatty liver disease (NAFLD) is of concern for its progression to insulin resistance, steatohepatitis and cardiovascular disease (CVD). The increased uptake of fatty acids in critical organs plays a major role in NAFLD progression. Male Ceacam1−/− mice that develop NAFLD, insulin resistance and CVD on normal chow are a potential model for studying the dysregulation of fatty acid uptake. [18F]fluoro-4-thia-oleate ([18F]FTO) was chosen as a fatty acid reporter because of its higher uptake and retention in the heart in an animal model of CVD. Male wild-type (WT) or Ceacam1−/− mice fasted 4–6 h were administered [18F]FTO i.v., and dynamic PET scans were conducted in an MR/PET small animal imaging system along with terminal tissue biodistributions. Quantitative heart image analysis revealed significantly higher uptake at 35 min in Ceacam1−/− (6.0 ± 1.0% ID/cc) vs. WT (3.9 ± 0.6% ID/cc) mice (p = 0.006). Ex vivo heart uptake/retention (% ID/organ) was 2.82 ± 0.45 for Ceacam1−/− mice vs. 1.66 ± 0.45 for WT mice (p < 0.01). Higher kidney and pancreas uptake/retention in Ceacam1−/− was also evident, and the excretion of [18F]FTO into the duodenum was observed for both WT and Ceacam1−/− mice starting at 10 min. This study suggests that the administration of [18F]FTO as a marker of fatty acid uptake and retention may be an important tool in analyzing the effect of NAFLD on lipid dysregulation in the heart. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 15121577 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/15/12/1577; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph15121577 |
| URL الوصول: | https://doaj.org/article/3f9c736a80a54457bdf7222f4732c34c |
| رقم الأكسشن: | edsdoj.3f9c736a80a54457bdf7222f4732c34c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15121577 14248247 |
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| DOI: | 10.3390/ph15121577 |