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Predicting anxiety from wholebrain activity patterns to emotional faces in young adults: a machine learning approach

التفاصيل البيبلوغرافية
العنوان: Predicting anxiety from wholebrain activity patterns to emotional faces in young adults: a machine learning approach
المؤلفون: Liana C.L. Portugal, Jessica Schrouff, Ricki Stiffler, Michele Bertocci, Genna Bebko, Henry Chase, Jeanette Lockovitch, Haris Aslam, Simona Graur, Tsafrir Greenberg, Mirtes Pereira, Leticia Oliveira, Mary Phillips, Janaina Mourão-Miranda
المصدر: NeuroImage: Clinical, Vol 23, Iss , Pp - (2019)
بيانات النشر: Elsevier, 2019.
سنة النشر: 2019
المجموعة: LCC:Computer applications to medicine. Medical informatics
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
الوصف: Background: It is becoming increasingly clear that pathophysiological processes underlying psychiatric disorders categories are heterogeneous on many levels, including symptoms, disease course, comorbidity and biological underpinnings. This heterogeneity poses challenges for identifying biological markers associated with dimensions of symptoms and behaviour that could provide targets to guide treatment choice and novel treatment. In response, the research domain criteria (RDoC) (Insel et al., 2010) was developed to advocate a dimensional approach which omits any disease definitions, disorder thresholds, or cut-points for various levels of psychopathology to understanding the pathophysiological processes underlying psychiatry disorders. In the present study we aimed to apply pattern regression analysis to identify brain signatures during dynamic emotional face processing that are predictive of anxiety and depression symptoms in a continuum that ranges from normal to pathological levels, cutting across categorically-defined diagnoses. Methods: The sample was composed of one-hundred and fifty-four young adults (mean age=21.6 and s.d.=2.0, 103 females) consisting of eighty-two young adults seeking treatment for psychological distress that cut across categorically-defined diagnoses and 72 matched healthy young adults. Participants performed a dynamic face task involving fearful, angry and happy faces (and geometric shapes) while undergoing functional Magnetic Resonance Imaging (fMRI). Pattern regression analyses consisted of Gaussian Process Regression (GPR) implemented in the Pattern Recognition for Neuroimaging toolbox (PRoNTo). Predicted and actual clinical scores were compared using Pearson's correlation coefficient (r) and normalized mean squared error (MSE) to evaluate the models' performance. Permutation test was applied to estimate significance levels. Results: GPR identified patterns of neural activity to dynamic emotional face processing predictive of self-report anxiety in the whole sample, which covered a continuum that ranged from healthy to different levels of distress, including subthreshold to fully-syndromal psychiatric diagnoses. Results were significant using two different cross validation strategies (two-fold: r=0.28 (p-value=0.001), MSE=4.47 (p-value=0.001) and five fold r=0.28 (p-value=0.002), MSE=4.62 (p-value=0.003). The contributions of individual regions to the predictive model were very small, demonstrating that predictions were based on the overall pattern rather than on a small combination of regions. Conclusions: These findings represent early evidence that neuroimaging techniques may inform clinical assessment of young adults irrespective of diagnoses by allowing accurate and objective quantitative estimation of psychopathology. Keywords: RDoC, Anxiety, Depression, fMRI, Pattern recognition, Pattern regression analysis, Machine learning, Faces, MVPA
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2213-1582
Relation: http://www.sciencedirect.com/science/article/pii/S2213158219301639; https://doaj.org/toc/2213-1582
DOI: 10.1016/j.nicl.2019.101813
URL الوصول: https://doaj.org/article/3fd1dd0f9c484348ae73d90a3e3c6a6a
رقم الأكسشن: edsdoj.3fd1dd0f9c484348ae73d90a3e3c6a6a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22131582
DOI:10.1016/j.nicl.2019.101813