دورية أكاديمية
Prospects of using genetic testing to increase the effectiveness of antihypertensive therapy
| العنوان: | Prospects of using genetic testing to increase the effectiveness of antihypertensive therapy |
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| المؤلفون: | N. V. Drobotya, L. V. Arutyunyan, A. A. Pirozhenko, V. V. Kaltykova |
| المصدر: | Российский кардиологический журнал, Vol 25, Iss 5 (2020) |
| بيانات النشر: | «FIRMA «SILICEA» LLC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | hypertension, gene polymorphism, renin-angiotensin-aldosterone system, angiotensin-converting enzyme inhibitor, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Aim. To compare the effects of 3-month therapy with a fixed-dose combination of an angiotensin-converting enzyme inhibitor (perindopril) and a thiazide-like diuretic (indapamide) in genetically heterogeneous subgroups of patients with hypertension (HTN) for assessing the prospects of using genetic testing for choosing the antihypertensive treatment regimen.Material and methods. Forty-one patients with grade 1-2 HTN with insufficient effectiveness of previous antihypertensive therapy and 20 healthy individuals were examined to compare the prevalence of gene polymorphism in the Rostov Oblast. Patients with HTN underwent standard diagnostic tests, as well as a molecular genetic test to determine the most clinically significant polymorphic genes involved in the pathogenesis of HTN.Results. A relationship was found between the clinical and morphofunctional characteristics of HTN in patients with polymorphisms of AGT, AGTR2, CYP11B2, GNB3, and NOS3 -786 genes, of which 3 polymorphic genes (AGT, AGTR2, CYP11B2) encode the activity of the angiotensin-converting enzyme. The effectiveness of using a combination of renin-angiotensin-aldosterone system inhibitor agent with a thiazide-like diuretic as an initial antihypertensive therapy was evaluated.An analysis showed that fixed-dose combination of perindopril (10,0) and indapamide (2,5) (Noliprel A Bi-forte) in genetically heterogeneous subgroups of HTN patients displays a more pronounced antihypertensive and organ-protective effects in individuals with the mutant allele 704C of AGT T704C polymorphism. A significant decrease in blood pressure was demonstrated according to standard 24-hour monitoring (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1560-4071 2618-7620 |
| Relation: | https://russjcardiol.elpub.ru/jour/article/view/3911; https://doaj.org/toc/1560-4071; https://doaj.org/toc/2618-7620 |
| DOI: | 10.15829/1560-4071-2020-3911 |
| URL الوصول: | https://doaj.org/article/4019b519f25e49e1817900e09da618b1 |
| رقم الأكسشن: | edsdoj.4019b519f25e49e1817900e09da618b1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15604071 26187620 |
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| DOI: | 10.15829/1560-4071-2020-3911 |