دورية أكاديمية
Microstructure of the superior temporal gyrus and hallucination proneness - a multi-compartment diffusion imaging study
| العنوان: | Microstructure of the superior temporal gyrus and hallucination proneness - a multi-compartment diffusion imaging study |
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| المؤلفون: | Amy Spray, Anton L. Beer, Richard P. Bentall, Vanessa Sluming, Georg Meyer |
| المصدر: | NeuroImage: Clinical, Vol 20, Iss , Pp 1-6 (2018) |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Previous studies reported that the volume of the left superior temporal gyrus (STG) is reduced in patients with schizophrenia and negatively correlated with hallucination severity. Moreover, diffusion-tensor imaging studies suggested a relationship between the brain microstructure in the STG of patients and auditory hallucinations. Hallucinations are also experienced in non-patient groups. This study investigated the relationship between hallucination proneness and the brain structure of the STG.Hallucination proneness was assessed by the Launey Slade Hallucination Scale (LSHS) in 25 healthy individuals who varied in their propensity to hear voices. Brain volume and microstructure of the STG was assessed by magnetic resonance imaging (MRI). Microstructure was examined by conventional diffusion-tensor imaging as well as by neurite orientation dispersion and density imaging (NODDI). The latter decomposes diffusion-based MRI into multiple compartments that characterize the brain microstructure by its neurite complexity known as orientation dispersion (ODI) and by its neurite density (NDI).Hallucination proneness was negatively correlated with the volume and microstructure (fractional anisotropy, neurite complexity) of the left but not the right STG. The strongest relationship (r = −0.563) was observed for neurite complexity (ODI). No correlation was observed for neurite density (NDI).These findings suggest that there is a relationship between the volume and the microstructure of the left STG and hallucination proneness. Dendritic complexity (but not neurite density) is inversely related to hallucination proneness. Metrics based on multi-compartment diffusion models seem to be more sensitive for hallucination-related neural processes than conventional MRI-based metrics. Keywords: Hallucination, Superior temporal gyrus, LSHS, Schizophrenia, NODDI, Diffusion MRI |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158218302109; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2018.06.027 |
| URL الوصول: | https://doaj.org/article/c401b33f067246f293aa2b2e53ad4ebf |
| رقم الأكسشن: | edsdoj.401b33f067246f293aa2b2e53ad4ebf |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2018.06.027 |